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Scientific paper - Review paper
The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury
Pharmaceuticals, 17 (2024), 10; 1313. https://doi.org/10.3390/ph17101313
Harej Hrkać, Anja; Pilipović, Kristina; Belančić, Andrej; Juretić, Lea; Vitezić, Dinko; Mršić-Pelčić, Jasenka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Harej Hrkać, A., Pilipović, K., Belančić, A., Juretić, L., Vitezić, D. & Mršić Pelčić, J. (2024). The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury. Pharmaceuticals, 17. (10). doi: 10.3390/ph17101313

Harej Hrkać, Anja, et al. "The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury." Pharmaceuticals, vol. 17, no. 10, 2024. https://doi.org/10.3390/ph17101313

Harej Hrkać, Anja, Kristina Pilipović, Andrej Belančić, Lea Juretić, Dinko Vitezić and Jasenka Mršić Pelčić. "The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury." Pharmaceuticals 17, no. 10 (2024). https://doi.org/10.3390/ph17101313

Harej Hrkać, A., et al. (2024) 'The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury', Pharmaceuticals, 17(10). doi: 10.3390/ph17101313

Harej Hrkać A, Pilipović K, Belančić A, Juretić L, Vitezić D, Mršić Pelčić J. The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury. Pharmaceuticals [Internet]. 2024 October 01 [cited 2024 November 09];17(10). doi: 10.3390/ph17101313

A. Harej Hrkać, K. Pilipović, A. Belančić, L. Juretić, D. Vitezić and J. Mršić Pelčić, "The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury", Pharmaceuticals, vol. 17, no. 10, October 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:467040. [Accessed: 09 November 2024]

Metadata
Title (english)The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury
AuthorAnja Harej Hrkać
AuthorKristina Pilipović
AuthorAndrej Belančić
AuthorLea Juretić
AuthorDinko Vitezić
AuthorJasenka Mršić-Pelčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Abstract (english)
Traumatic brain injury (TBI), which is a global public health concern, can take various forms, from mild concussions to blast injuries, and each damage type has a particular mechanism of progression. However, TBI is a condition with complex pathophysiology and heterogenous clinical presentation, which makes it difficult to model for in vitro and in vivo studies and obtain relevant results that can easily be translated to the clinical setting. Accordingly, the pharmacological options for TBI management are still scarce. Since a wide spectrum of processes, such as glucose homeostasis, food intake, body temperature regulation, stress response, neuroprotection, and memory, were demonstrated to be modulated after delivering glucagon-like peptide 1 (GLP-1) or GLP-1 receptor agonists into the brain, we aimed to speculate on their potential role in TBI management by comprehensively overviewing the preclinical and clinical body of evidence. Based on promising preclinical data, GLP-1 receptor agonists hold the potential to extend beyond metabolic disorders and address unmet needs in neuroprotection and recovery after TBI, but also other types of central nervous system injuries such as the spinal cord injury or cerebral ischemia. This overview can lay the basis for tailoring new research hypotheses for future in vitro and in vivo models in TBI settings. However, large-scale clinical trials are crucial to confirm their safety and efficacy in these new therapeutic applications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 17, no. 10, 1313
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph17101313
URN:NBNurn:nbn:hr:184:467040
Publication2024-10-01
Document URLhttps://www.mdpi.com/1424-8247/17/10/1313
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-03 09:33:24