prikaz prve stranice dokumenta The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
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Scientific paper - Review paper
The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
International Journal of Molecular Sciences, 25 (2024), 20; 10891. https://doi.org/10.3390/ijms252010891
Ćurko-Cofek, Božena; Jenko, Matej; Taleska Stupica, Gordana; Batičić, Lara; Krsek, Antea; Batinac, Tanja; Ljubačev, Aleksandra; Zdravković, Marko; Knežević, Danijel; Šoštarič, Maja; Sotošek, Vlatka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Ćurko Cofek, B., Jenko, M., Taleska Stupica, G., Batičić, L., Krsek, A., Batinac, T. ... Sotošek, V. (2024). The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections. International Journal of Molecular Sciences, 25. (20). doi: 10.3390/ijms252010891

Ćurko Cofek, Božena, et al. "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections." International Journal of Molecular Sciences, vol. 25, no. 20, 2024. https://doi.org/10.3390/ijms252010891

Ćurko Cofek, Božena, Matej Jenko, Gordana Taleska Stupica, Lara Batičić, Antea Krsek, Tanja Batinac, Aleksandra Ljubačev, et al. "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections." International Journal of Molecular Sciences 25, no. 20 (2024). https://doi.org/10.3390/ijms252010891

Ćurko Cofek, B., et al. (2024) 'The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections', International Journal of Molecular Sciences, 25(20). doi: 10.3390/ijms252010891

Ćurko Cofek B, Jenko M, Taleska Stupica G, Batičić L, Krsek A, Batinac T, and sur.. The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections. International Journal of Molecular Sciences [Internet]. 2024 October 10 [cited 2024 November 30];25(20). doi: 10.3390/ijms252010891

B. Ćurko Cofek, et al., "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections", International Journal of Molecular Sciences, vol. 25, no. 20, October 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:543128. [Accessed: 30 November 2024]

Metadata
Title (english)The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
AuthorBožena Ćurko-Cofek
AuthorMatej Jenko
AuthorGordana Taleska Stupica
AuthorLara Batičić
AuthorAntea Krsek
AuthorTanja Batinac
AuthorAleksandra Ljubačev
AuthorMarko Zdravković
AuthorDanijel Knežević
AuthorMaja Šoštarič
AuthorVlatka Sotošek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Since its introduction, the number of heart surgeries has risen continuously. It is a high-risk procedure, usually involving cardiopulmonary bypass, which is associated with an inflammatory reaction that can lead to perioperative and postoperative organ dysfunction. The extent of complications following cardiac surgery has been the focus of interest for several years because of their impact on patient outcomes. Recently, numerous scientific efforts have been made to uncover the complex mechanisms of interaction between inflammation, oxidative stress, and endothelial dysfunction that occur after cardiac surgery. Numerous factors, such as surgical and anesthetic techniques, hypervolemia and hypovolemia, hypothermia, and various drugs used during cardiac surgery trigger the development of systemic inflammatory response and the release of oxidative species. They affect the endothelium, especially endothelial glycocalyx (EG), a thin surface endothelial layer responsible for vascular hemostasis, its permeability and the interaction between leukocytes and endothelium. This review highlights the current knowledge of the molecular mechanisms involved in endothelial dysfunction, particularly in the degradation of EG. In addition, the major inflammatory events and oxidative stress responses that occur in cardiac surgery, their interaction with EG, and the clinical implications of these events have been summarized and discussed in detail. A better understanding of the complex molecular mechanisms underlying cardiac surgery, leading to endothelial dysfunction, is needed to improve patient management during and after surgery and to develop effective strategies to prevent adverse outcomes that complicate recovery.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 20, 10891
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252010891
URN:NBNurn:nbn:hr:184:543128
Publication2024-10-10
ProjectNumber: IPS-2023-02-9650
Title (croatian): Endotelna disfunkcija, upala i oksidacijski stres u kardiokirurških bolesnika
Title (english): Endothelial dysfunction, inflammation and oxidative stress in patients undergoing cardiac surgery
Acronym: EDIOS
Leader: Vlatka Sotošek Tokmadžić
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/1422-0067/25/20/10891
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-11 06:51:39