prikaz prve stranice dokumenta Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
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Scientific paper - Original scientific paper
Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
JCI Insight, 9 (2024), 11; e175525.. https://doi.org/10.1172/jci.insight.175525
Sung, Cathy Yea Won; Li, Mao; Jonjić, Stipan; Sanchez, Veronica; Britt, William J.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Sung, C. Y. W., Li, M., Jonjić, S., Sanchez, V. & Britt, W. J. (2024). Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development. JCI Insight, 9. (11). doi: 10.1172/jci.insight.175525

Sung, Cathy Yea Won, et al. "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development." JCI Insight, vol. 9, no. 11, 2024. https://doi.org/10.1172/jci.insight.175525

Sung, Cathy Yea Won, Mao Li, Stipan Jonjić, Veronica Sanchez and William J. Britt. "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development." JCI Insight 9, no. 11 (2024). https://doi.org/10.1172/jci.insight.175525

Sung, C. Y. W., et al. (2024) 'Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development', JCI Insight, 9(11). doi: 10.1172/jci.insight.175525

Sung CYW, Li M, Jonjić S, Sanchez V, Britt WJ. Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development. JCI Insight [Internet]. 2024 June 10 [cited 2024 November 26];9(11). doi: 10.1172/jci.insight.175525

C. Y. W. Sung, M. Li, S. Jonjić, V. Sanchez and W. J. Britt, "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development", JCI Insight, vol. 9, no. 11, June 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:098595. [Accessed: 26 November 2024]

Metadata
Title (english)Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
AuthorCathy Yea Won Sung
AuthorMao Li
AuthorStipan Jonjić
AuthorVeronica Sanchez
AuthorWilliam J. Britt
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus (HCMV) infection in infants infected in utero can lead to a variety of neurodevelopmental disorders. However, mechanisms underlying altered neurodevelopment in infected infants remain poorly understood. We have previously described a murine model of congenital HCMV infection in which murine CMV (MCMV) spreads hematogenously and establishes a focal infection in all regions of the brain of newborn mice, including the cerebellum. Infection resulted in disruption of cerebellar cortical development characterized by reduced cerebellar size and foliation. This disruption was associated with altered cell cycle progression of the granule cell precursors (GCPs), which are the progenitors that give rise to granule cells (GCs), the most abundant neurons in the cerebellum. In the current study, we have demonstrated that MCMV infection leads to prolonged GCP cell cycle, premature exit from the cell cycle, and reduced numbers of GCs resulting in cerebellar hypoplasia. Treatment with TNF-α neutralizing antibody partially normalized the cell cycle alterations of GCPs and altered cerebellar morphogenesis induced by MCMV infection. Collectively, our results argue that virus-induced inflammation altered the cell cycle of GCPs resulting in a reduced numbers of GCs and cerebellar cortical hypoplasia, thus providing a potential mechanism for altered neurodevelopment in fetuses infected with HCMV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJCI Insight
Numberingvol. 9, no. 11, e175525.
e-ISSN2379-3708
DOIhttps://doi.org/10.1172/jci.insight.175525
URN:NBNurn:nbn:hr:184:098595
Publication2024-06-10
Document URLhttps://insight.jci.org/articles/view/175525
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2024-11-11 13:27:00