prikaz prve stranice dokumenta Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
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Scientific paper - Original scientific paper
Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
International Journal of Molecular Sciences, 25 (2024), 21; 11712. https://doi.org/10.3390/ijms252111712
Gašparović Krpina, Milena; Dević Pavlić, Sanja; Mladenić, Tea; Aralica, Merica; Barišić, Anita; Brnčić-Fischer, Alemka; Ostojić, Saša; Pereza, Nina

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Gašparović Krpina, M., Dević Pavlić, S., Mladenić, T., Aralica, M., Barišić, A., Brnčić Fischer, A. ... Pereza, N. (2024). Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population. International Journal of Molecular Sciences, 25. (21). doi: 10.3390/ijms252111712

Gašparović Krpina, Milena, et al. "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population." International Journal of Molecular Sciences, vol. 25, no. 21, 2024. https://doi.org/10.3390/ijms252111712

Gašparović Krpina, Milena, Sanja Dević Pavlić, Tea Mladenić, Merica Aralica, Anita Barišić, Alemka Brnčić Fischer, Saša Ostojić and Nina Pereza. "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population." International Journal of Molecular Sciences 25, no. 21 (2024). https://doi.org/10.3390/ijms252111712

Gašparović Krpina, M., et al. (2024) 'Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population', International Journal of Molecular Sciences, 25(21). doi: 10.3390/ijms252111712

Gašparović Krpina M, Dević Pavlić S, Mladenić T, Aralica M, Barišić A, Brnčić Fischer A, and sur.. Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population. International Journal of Molecular Sciences [Internet]. 2024 October 31 [cited 2024 November 23];25(21). doi: 10.3390/ijms252111712

M. Gašparović Krpina, et al., "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population", International Journal of Molecular Sciences, vol. 25, no. 21, October 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:597602. [Accessed: 23 November 2024]

Metadata
Title (english)Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
AuthorMilena Gašparović Krpina
AuthorSanja Dević Pavlić
AuthorTea Mladenić
AuthorMerica Aralica
AuthorAnita Barišić
AuthorAlemka Brnčić-Fischer
AuthorSaša Ostojić
AuthorNina Pereza
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Preterm birth (PTB) forms a heterogeneous group with possible genetic predisposition. 25(OH)-vitamin D3 plays a significant role during implantation, placentation, and the maintenance of normal pregnancy. The aim of our research was to examine whether FokI, Cdx2, and ApaI VDR gene variants, as well as serum concentrations of 25-hydroxy25(OH)-vitamin D3 in women and their newborns, might be predisposing factors for idiopathic spontaneous preterm birth. The patient group consisted of 44 pairs of women with ISPTB and their children, and the control group consisted of 44 pairs of women who delivered at term and their children. At the time of delivery, peripheral blood was collected from every woman, and after newborn delivery, umbilical cord blood was collected. For genotyping of the rs2228570 C/T, rs11568820 G/A, and rs7975232 T/G SNPs, a combination of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was used. Serum concentrations of 25(OH)-vitamin D3 were determined using high-performance liquid chromatography (HPLC). There were no statistically significant differences in the frequencies of VDR genotypes and alleles between women with ISPTB and control women. There was a statistically significant difference in the distribution of VDR Cdx-2 (rs11568820) genotypes between preterm-born children and controls, with the GG genotype and G allele being more prevalent among patients than controls (p < 0.001). There were no statistically significant differences in mean values between women with ISPTB and control women, nor between preterm and full-term newborns, although the 25(OH)-vitamin D3 concentrations in preterm-born children were lower than in controls. Furthermore, there was a statistically significant correlation in 25(OH)-vitamin D3 concentrations between mothers and children both in the patient and in the control groups (b = 0.771, p < 0.001). The results of our study demonstrate a notable association between the VDR Cdx2 gene polymorphism and idiopathic spontaneous preterm birth (ISPTB) in a Caucasian population, but because of the small number of participants, further research is needed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 21, 11712
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252111712
URN:NBNurn:nbn:hr:184:597602
Publication2024-10-31
Document URLhttps://www.mdpi.com/1422-0067/25/21/11712
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-13 08:10:23