prikaz prve stranice dokumenta Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
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Scientific paper - Original scientific paper
Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
International Journal of Molecular Sciences, 25 (2024), 24; 13287. https://doi.org/10.3390/ijms252413287
Dević Pavlić, Sanja; Saftić Martinović, Lara; Sušanj Šepić, Tina; Radojčić Badovinac, Anđelka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Dević Pavlić, S., Saftić Martinović, L., Sušanj Šepić, T. & Radojčić Badovinac, A. (2024). Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART). International Journal of Molecular Sciences, 25. (24). doi: 10.3390/ijms252413287

Dević Pavlić, Sanja, et al. "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)." International Journal of Molecular Sciences, vol. 25, no. 24, 2024. https://doi.org/10.3390/ijms252413287

Dević Pavlić, Sanja, Lara Saftić Martinović, Tina Sušanj Šepić and Anđelka Radojčić Badovinac. "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)." International Journal of Molecular Sciences 25, no. 24 (2024). https://doi.org/10.3390/ijms252413287

Dević Pavlić, S., et al. (2024) 'Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)', International Journal of Molecular Sciences, 25(24). doi: 10.3390/ijms252413287

Dević Pavlić S, Saftić Martinović L, Sušanj Šepić T, Radojčić Badovinac A. Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART). International Journal of Molecular Sciences [Internet]. 2024 December 11 [cited 2025 January 11];25(24). doi: 10.3390/ijms252413287

S. Dević Pavlić, L. Saftić Martinović, T. Sušanj Šepić and A. Radojčić Badovinac, "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)", International Journal of Molecular Sciences, vol. 25, no. 24, December 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:644781. [Accessed: 11 January 2025]

Metadata
Title (english)Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
AuthorSanja Dević Pavlić
AuthorLara Saftić Martinović
AuthorTina Sušanj Šepić
AuthorAnđelka Radojčić Badovinac
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
This study investigated the influence of two in vitro fertilization (IVF) protocols—controlled ovarian hyperstimulation (COH) and a modified natural cycle protocol—on gene expression levels (Anti-Müllerian Hormone (AMH), Anti-Müllerian Hormone Receptor Type 2 (AMHAMHR2), Follicle-Stimulating Hormone Receptor (FSHR), and Androgen Receptor (AR)) and the subsequent reproductive outcomes of assisted reproductive technology (ART). Gene expression, as well as oocyte, zygote, and embryo morphological parameters, were analyzed to evaluate the differences between the protocols. Our findings show that AMH expression was significantly associated with successful fertilization, while AMHAMHR2 expression correlated with improved embryo transfer outcomes. The modified natural cycle protocol demonstrated a higher association with the favorable gene expression profiles, particularly for AMH and AMHAMHR2, linked to successful fertilization and embryo transfer, suggesting potential advantages of minimal intervention. However, the overall quality scores for the oocytes, zygotes, and embryos were comparable between the protocols. The trend of a higher transfer success for the natural cycle, though not statistically significant, indicated potential protocol effects on the uterine environment. This study highlights the complexity of ART outcomes and suggests that incorporating gene expression markers with protocol adjustments may optimize individual ART strategies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 24, 13287
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252413287
URN:NBNurn:nbn:hr:184:644781
Publication2024-12-11
Document URLhttps://www.mdpi.com/1422-0067/25/24/13287
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-13 09:54:27