Patients with intoxications are a common case in the emergency department. Their clinical presentation depends on the type of toxic substance and the dose to which they were exposed. Certain substances can cause characteristic groups of symptoms known as toxidromes. Treatment is in most cases symptomatic. The aim of this study was to analyse the characteristics and clinical data of patients with intoxications in the Emergency Department of University Hospital Centre Zagreb. A retrospective analysis was conducted on 138 patients of the Emergency Department of UHC Zagreb over a six-month period with a diagnosis of intoxication. Demografic and clinical data were collected from the patient's medical records. For easier data analysis, intoxications were divided into five categories according to the type of toxic substance; alcohol, psychotropic drugs, other medications, addictive substances and other intoxications. Patients with intoxications comprised 0,8% od all non-surgical patients in the Emergency Department. The most common were alcohol intoxications, accounting for 47,8% of cases, followed by psychotropic drug intoxications at 18,1%. Intoxications with addictive substances and other intoxications were equally represented, while the least common were intoxications with other drugs. Among psychotropic drugs, benzodiazepines were the most common cause of poisoning, making them the second most prevalent substance in this study, after alcohol. Most intoxications were intentional, generally presented with mild symptoms, and had a good outcome. Doctors in the emergency department encounter various types of intoxications, with alcohol and drug intoxications being the most common. Clinical presentation can range from mild symptoms to life-threatening conditions. Therefore, good planning and education are necessary, for which this study can provide a foundation.