Title Epilepsija i psihoza
Title (english) Epilepsy and psychosis
Author Dora Učkar
Mentor Željka Petelin Gadže (mentor)
Committee member Martina Rojnić Kuzman (predsjednik povjerenstva)
Committee member Mario Habek (član povjerenstva)
Committee member Željka Petelin Gadže (član povjerenstva)
Granter University of Zagreb School of Medicine (Department of Neurology) Zagreb
Defense date and country 2024-07-12, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract Epilepsija je jedna od najčešćih neuroloških bolesti od koje u svijetu trenutno boluje oko 50 milijuna ljudi, čineći je značajnim medicinskim i socijalnim problemom. Definirana je kao bolest mozga karakterizirana stalnom predispozicijom za nastanak epileptičkih napadaja, uz prateće neurobiološke, psihološke, kognitivne i socijalne posljedice tog stanja. Prema smjernicama Internacionalne lige protiv epilepsije (ILAE) iz 2017. godine, epilepsije prema etiologiji možemo podijeliti na genske,
... More strukturalne, metaboličke, imunosno-posredovane, epilepsije uzrokovane infekcijama središnjeg živčanog sustava (SŽS), te epilepsije nepoznate etiologije. Zahvaljujući napretku dijagnostičkih postupaka i terapijskih opcija, epilepsija je jedna od neuroloških bolesti koja se u većine pacijenata može zadovoljavajuće liječiti. Psihijatrijski poremećaji javljaju se u 20 - 30% osoba s epilepsijom, a stopa psihotičnih poremećaja u ovoj je populaciji 6 do 12 puta veća nego u općoj populaciji. Psihoza nije dijagnoza, već klinički sindrom čije je glavno obilježje pogrešna percepcija stvarnosti koja se manifestira pojavom sumanutosti, halucinacija, dezorganiziranog mišljenja i ponašanja, negativnih simptoma, afektivnih simptoma te abnormalne psihomotorike. Psihoza je relativno rijedak komorbiditet u bolesnika s epilepsijom, ali jedan od najistaknutijih psihotičnih poremećaja zbog drugog zdravstvenog stanja. S obzirom na vremensku povezanost s napadajem, može se podijeliti na iktalnu, postiktalnu (PIP) i interiktalnu (IIP), od kojih je potonja najčešća. Prevalencija psihoze najveća je kod žarišne epilepsije, posebice one koja zahvaća medijalni temporalni režanj. Uzrok nastanka je i dalje nepoznat, a dosadašnja saznanja sugeriraju na zajedničku patofiziološku i genetsku podlogu. Ovaj komorbiditet predstavlja izazov u liječenju i zahtijeva individualan i multidisciplinarni pristup s ciljem pobošljanja kvalitete života pacijenta. Less
Abstract (english) Epilepsy is one of the most common neurological diseases, currently affecting around 50 million people worldwide, making it a significant medical and social issue. It is defined as a brain disorder characterized by a persistent predisposition to epileptic seizures, accompanied by neurobiological, psychological, cognitive, and social consequences of this condition. According to the 2017 guidelines from the International League Against Epilepsy (ILAE), epilepsy can be classified by
... More ethiology as genetic, structural, metabolic, immune-mediated, epilepsy caused by central nervous system (CNS) infections, and epilepsy of unknown etiology. Thanks to advancements in diagnostic procedures and therapeutic options, epilepsy is one of the neurological diseases that can be successfully treated in the majority of patients. Psychiatric disorders occur in 20-30% of people with epilepsy, and the rate of psychotic disorders in this population is 6 to 12 times higher than in the general population. Psychosis is not a diagnosis per se, but a clinical syndrome whose main characteristic is distorted perception of reality, which manifests with delusions, halucinations, disorganized thinking and behavior, changes in affect, negative symptoms and psychomotoric abnormalities. Psychosis of epilepsy is a rare comorbidity in patients with epilepsy, but one of the most prominent psychotic disorders due to another medical condition. It can be classified according to its temporal relation with seizures as ictal, postictal (PIP) or intertictal (IIP), with the latter being the most common. The prevalence of psychosis is highest in patients with focal epilepsy, especially those with medial temporal lobe involvement. The cause of onset remains unknown, and current knowledge suggests a common pathophysiological and genetic basis. This comorbidity presents a challenge in treatment and requires an individualized and multidisciplinary approach to improve the patient's quality of life. Less
Keywords
epilepsija
ILAE
psihoza
halucinacije
sumanutosti
Keywords (english)
epilepsy
ILAE
psychosis
halucinations
delusions
Language croatian
URN:NBN urn:nbn:hr:105:729548
Study programme Title: Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2024-07-05 11:19:08