prikaz prve stranice dokumenta Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre
Embargo period 2026-07-03
doctoral thesis
Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:564008
Jurina, Andrija
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Jurina, A. (2024). Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:564008

Jurina, Andrija. "Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:564008

Jurina, Andrija. "Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:564008

Jurina, A. (2024). 'Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:564008

Jurina A. Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:564008

A. Jurina, "Povezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:564008

Metadata
TitlePovezanost čimbenika rasta fibroblasta 23 i gubitka koštane mase u kandidata za transplantaciju jetre
Title (english)Association between fibroblast growth factor 23 and bone loss in liver transplant candidates
AuthorAndrija Jurina
MentorMario Starešinić (mentor)
MentorMarijana Vučić Lovrenčić (komentor)
Committee memberZlatko Giljević (predsjednik povjerenstva)
Committee memberAnna Mrzljak (član povjerenstva)
Committee memberVesna Kušec (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-07-03, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Universal decimal classification
(UDC)		617 - Surgery. Orthopaedics. Ophthalmology
Abstract
Uvod: Jetrena osteodistrofija (engl. hepatic osteodistrophy, HO) je koštano-mineralni poremećaj u kandidata za ortotopnu transplantaciju jetre (OTJ) koju obilježava gubitak koštane mase i sklonost prijelomima. Čimbenik rasta fibroblasta 23 (engl. fibroblast growth factor 23, FGF23) regulira metabolizam fosfata i vitamina D, a povećane koncentracije se povezuju s gubitkom koštane mase i osteoporotskim prijelomima. Cilj ovog istraživanja je bio ispitati povezanost gubitka koštane mase i koncentracije intaktnog FGF23-a (engl. intact FGF23, iFGF23) u kandidata za OTJ. Ispitanici i metode: U istraživanje su uključeni odrasli kandidati za OTJ. Gubitak koštane mase (osteopenija ili osteoporoza) je dijagnosticiran s pomoću denzitometrije kosti X-zrakama dvostruke prodornosti (DXA), a prijelomi kralježnice standardnim radiološkim snimkama. Izmjerene su koncentracije parametara koštano-mineralnog metabolizma, upale, inzulinske rezistencije, iFGF23 i aktivnost koštane alkalne fosfataze (BALP) u krvi. Ispitanici su podijeljeni u skupinu bez i s gubitkom koštane mase. Rezultati: U istraživanje je uključeno 90 ispitanika (40 u skupini bez, a 50 u skupini s gubitkom koštane mase). Pojavnost gubitka koštane mase iznosila je 55,6%, a prijeloma kralježnice 48,9%. Nije bilo razlike statistički značajne razlike u parametrima koštano-mineralnog metabolizma, upale, inzulinske rezistencije te iFGF23-a između promatranih skupina. Aktivnost BALP-a bila je povećana u ispitanika s gubitkom koštane mase. Ženski spol i veća aktivnost BALP-a nezavisni su čimbenici rizika gubitka koštane mase, a starija životna dob prijeloma. Aktivnost BALP-a značajno je negativno korelirala s nalazom DXA. Zaključci: Pojavnost gubitka koštane mase i osteoporotskih prijeloma kralježnice u kandidata za OTJ je veća nego u zdravoj populaciji. Koncentracija iFGF23-a nije povezana s gubitkom koštane mase.
Abstract (english)
Introduction: Hepatic osteodystrophy (HO) is a bone-mineral disorder in orthotopic liver transplantation (OLT) candidates that leads to bone loss and tendency to fractures. Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D metabolism, and is associated with bone loss and fragility fractures. The aim of this study was to examine the relationship between bone loss and the concentration of intact FGF23 (iFGF23) in OLT candidates. Patients and methods: Adult OLT candidates were included in the study. Bone loss (osteopenia or osteoporosis) was diagnosed using dual-energy X-ray absorptiometry (DXA), and spinal fractures by standard radiological imaging. Parameters of bone-mineral metabolism, inflammation, insulin resistance, iFGF23 and bone alkaline phosphatase (BALP) activity were measured in blood. Patients were divided into groups with and without bone loss. Results: Ninety (90) patients were included in the study (40 in the group without and 50 in the group with bone loss). The bone loss prevalence was 55.6% and vertebral fractures 48.9%. No significant differences in parameters of bone-mineral metabolism, inflammation, insuline resistance and iFGF23 were found between groups. Group with bone loss had higher BALP activity. Female gender and higher values of bone alkaline phosphatase were independent risk factors for bone loss, while older age was for fractures. BALP activity significantly negatively correlated with DXA results. Conclusions: Prevalence of bone loss and osteoporotic fractures among OLT candidates is higher than in healthy population. No association exists between iFGF23 concentration and bone loss.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:564008
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent73 str.
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-07-03
Terms of useLicence In copyright icon
Created on2024-07-23 08:08:41