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professional thesis
Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:520681
Margeta, Ivan
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Margeta, I. (2024). Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama (Professional thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:520681

Margeta, Ivan. "Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama." Professional thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:520681

Margeta, Ivan. "Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama." Professional thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:520681

Margeta, I. (2024). 'Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama', Professional thesis, University of Zagreb, School of Medicine, accessed 04 October 2024, https://urn.nsk.hr/urn:nbn:hr:105:520681

Margeta I. Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama [Professional thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 October 04] Available at: https://urn.nsk.hr/urn:nbn:hr:105:520681

I. Margeta, "Procjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama", Professional thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:520681

Metadata
TitleProcjena staničnog imunog odgovora QuantiFERON Monitor testom u primatelja bubrega s infektivnim komplikacijama
Title (english)Evaluation of cell-mediated immune response by QuantiFERON Monitor Assay in kidney transplant recipients presenting with infective complications
AuthorIvan Margeta
MentorIvana Mareković (mentor)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-07-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Teško je procijeniti ukupnu razinu imunosupresije kod bolesnika s transplantiranim bubregom. QuantiFERON Monitor (QFM) je in vitro dijagnostički test koji mjeri razinu otpuštanja interferona-γ (IFN-γ) u perifernoj krvi. Cilj naše studije bilo je usporediti rezultate QFM testa kod stabilnih bolesnika s transplantiranim bubregom i kod bolesnika koji imaju akutno infektivno zbivanje. Istraživanje je provedeno u našem Centru te je uključen 71 bolesnik. Podijeljeni su u dvije skupine ovisno o kliničkoj slici (stabilni bolesnici ili bolesnici s akutnom infekcijom). Nije bilo statistički značajnih razlika u razini otpuštanja IFN-γ između dvije skupine bolesnika (stabilni bolesnici 140.59 ± 215.28 IU/ml, bolesnici s akutnom infekcijom 78.37 ± 197.03 IU/ml, P = .24). Dodatnom analizom nađena je statistički značajna razlika u otpuštanju interferona kod bolesnika s bakterijskim infekcijama u usporedbi sa stabilnim bolesnicima (26.52 ± 42.46 IU/ml vs 140.59 ± 215.28 IU/ml, P = .04). QFM test može biti koristan alat za pomoć prilikom vođenja imunosupresivne terapije kod bolesnika s transplantiranim bubregom, ali potrebne su daljnje studije kako bi se potvrdila njegova dijagnostička vrijednost.
Abstract (english)
The net level of immunosuppression in kidney transplant recipients is difficult to assess. QuantiFERON Monitor (QFM) is an in vitro diagnostic test that detects interferon-γ (IFN-γ) release in peripheral blood. The aim of our study was to compare QFM testing results in stable kidney transplant recipients and kidney transplant recipients with infection, in a single-centre cohort.We enrolled 71 kidney transplant recipients from our transplantation centre. They were divided into 2 groups according to clinical presentation (Stable kidney transplant recipients or Infection).There were no significant differences in interferon-γ release between the 2 groups (Stable kidney transplant recipients 140.59 ± 215.28 IU/ml, Infection group 78.37 ± 197.03 IU/ml, P = .24). A further analysis revealed that kidney transplant recipients presenting with bacterial infection had significantly lower IFN-γ release when compared to stable kidney transplant recipients (26.52 ± 42.46 IU/ml vs 140.59 ± 215.28 IU/ml, P = .04). Kidney transplant recipients presenting with bacterial infection had lower IFN-γ release when compared to stable kidney transplant recipients. The QFM test may be useful as a tool to help guide immunosuppression dosing in kidney transplant recipients, but further studies are required to confirm its diagnostic value.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:520681
Study programmeTitle: Nephrology
Study programme type: university
Study level: postgraduate specialist
Academic / professional title: sveučilišni/a magistar/magistra nefrologije (sveučilišni/a magistar/magistra nefrologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-08-21 10:40:44