prikaz prve stranice dokumenta Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI
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Scientific paper - Original scientific paper
Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI
Journal of the American Heart Association, 12 (2023), 17; e028942. https://doi.org/10.1161/JAHA.122.028942
Wang, Xiaowen; Jering, Karola S.; Čikeš, Maja; Tokmakova, Mariya P.; Mehran, Roxana; Han, Yaling; East, Cara; Mody, Freny Vaghaiwalla; Wang, Yi; Lewis, Eldrin F.; Claggett, Brian; McMurray, John J. V.; Granger, Christopher B.; Pfeffer, Marc A.; Solomon, Scott D. More authors...

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Wang, X., Jering, K. S., Čikeš, M., Tokmakova, M. P., Mehran, R., Han, Y. ... Solomon, S. D. (2023). Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI. Journal of the American Heart Association, 12. (17). doi: 10.1161/JAHA.122.028942

Wang, Xiaowen, et al. "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI." Journal of the American Heart Association, vol. 12, no. 17, 2023. https://doi.org/10.1161/JAHA.122.028942

Wang, Xiaowen, Karola S. Jering, Maja Čikeš, Mariya P. Tokmakova, Roxana Mehran, Yaling Han, Cara East, et al. "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI." Journal of the American Heart Association 12, no. 17 (2023). https://doi.org/10.1161/JAHA.122.028942

Wang, X., et al. (2023) 'Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI', Journal of the American Heart Association, 12(17). doi: 10.1161/JAHA.122.028942

Wang X, Jering KS, Čikeš M, Tokmakova MP, Mehran R, Han Y, and sur.. Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI. Journal of the American Heart Association [Internet]. 2023 September 05 [cited 2024 November 09];12(17). doi: 10.1161/JAHA.122.028942

X. Wang, et al., "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI", Journal of the American Heart Association, vol. 12, no. 17, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:310370. [Accessed: 09 November 2024]

Metadata
Title (english)Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI
AuthorXiaowen Wang
AuthorKarola S. Jering
AuthorMaja Čikeš
AuthorMariya P. Tokmakova
AuthorRoxana Mehran
AuthorYaling Han
AuthorCara East
AuthorFreny Vaghaiwalla Mody
AuthorYi Wang
AuthorEldrin F. Lewis
AuthorBrian Claggett
AuthorJohn J. V. McMurray
AuthorChristopher B. Granger
AuthorMarc A. Pfeffer
AuthorScott D. Solomon
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background Studies demonstrated sex differences in outcomes following acute myocardial infarction, with women more likely to develop heart failure (HF). Sacubitril/valsartan has been shown to reduce cardiovascular death and HF hospitalizations in patients with HF with reduced ejection fraction. Methods and Results A total of 5661 patients (1363 women [24%]) with acute myocardial infarction complicated by reduced left ventricular ejection fraction (≤40%), pulmonary congestion, or both and ≥1 of 8 risk-augmenting factors were randomized to receive sacubitril/valsartan or ramipril. The primary outcome was cardiovascular death or incident HF. Baseline characteristics, clinical outcomes, and safety events were compared according to sex, a prespecified subgroup. Female participants were older and had more comorbidities. After multivariable adjustment, women and men were at similar risks for cardiovascular death or all-cause death. Women were more likely to have first HF hospitalization (hazard ratio [HR], 1.34 [95% CI, 1.05-1.70]; P=0.02) and total HF hospitalizations (HR, 1.39 [95% CI, 1.05-1.84]; P=0.02). Sex did not significantly modify the treatment effect of sacubitril/valsartan compared with ramipril on the primary outcome (P for interaction=0.11). Conclusions In contemporary patients who presented with reduced left ventricular ejection fraction, pulmonary congestion, or both, following acute myocardial infarction, women had a higher incidence of HF during follow-up. Sex did not modify the treatment effect of sacubitril/valsartan relative to ramipril.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of the American Heart Association
Numberingvol. 12, no. 17, e028942
e-ISSN2047-9980
DOIhttps://doi.org/10.1161/JAHA.122.028942
URN:NBNurn:nbn:hr:105:310370
Publication2023-09-05
Document URLhttps://www.ahajournals.org/doi/10.1161/JAHA.122.028942
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-08-26 07:54:14