Medications from the statin group lower blood cholesterol levels by inhibiting the enzyme HMG-CoA reductase. Over years of widespread use, additional pleiotropic effects of statins have been discovered. Statins have been shown to possess anti-inflammatory, antioxidant, anti-aggregatory, and antiproliferative properties. The main aim of this research was to determine the impact of these properties on the course and outcome of pneumonia. In this retrospective study, 149 patients who were treated at the Emergency Department of the Clinical Hospital Center Zagreb for pneumonia between January 1, 2023, and January 1, 2024, were observed. Indicators of disease severity (hypoxemia, tachycardia, fever, hypotension, ARI, disorientation during examination, hyperglycemia, hyponatremia, PSI, CURB-65, need for hospitalization, length of hospital stay, return to the emergency department for a related reason, and outcomes) were defined for patients on statin therapy and those without statins in their treatment. A correlation was found between statin therapy and the aforementioned indicators of disease severity. The PSI scale, presence of tachycardia, hypotension, ARI, need for oxygen therapy, and the percentage of hospitalized patients indicated a milder course of disease in patients on statin therapy, while the presence of disorientation and the outcome of the disease were similar in both patient groups. The results are consistent with those of other studies that have examined the effects of statins on other inflammatory diseases. Future prospective studies with a larger number of patients and clearly defined disease outcomes will complement the results of this research and more clearly define the potential practical application of the findings.