Pain is a unique and complex experience in human life. The perception of painful stimuli depends on numerous factors such as genetic inheritance, environment, emotions, prior experiences, and individual characteristics. The onset of pain may be associated with tissue injury, but it is not always the case. Various scales, with the Visual Analog Scale (VAS) being the most effective, are used in diagnosing pain intensity. Pain therapy includes pharmacological and non-pharmacological methods. Pharmacological treatment is guided by the "WHO analgesic ladder". Mild pain is treated with weak analgesics that have fewer side effects, such as NSAIDs, acetaminophen, and adjuvant medications. For more intense or resistant pain, stronger analgesics like opioid analgesics are prescribed. Due to the risk of addiction and numerous side effects associated with opioids, physicians incorporate non-pharmacological methods into pain therapy. Non-pharmacological approaches may involve electrical currents, magnets, radiofrequency waves, and surgical interventions aimed at pain suppression. In addition to oral medications, pharmacological preparations can also be applied topically or invasively through regional blocks. When choosing the optimal therapy for a patient, physicians should consider all factors influencing pain perception and design a therapeutic treatment plan based on thorough medical history. To select the most effective treatment plan, physicians should be educated about all available treatment methods currently possible.