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Scientific paper - Review paper
The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
Current Issues in Molecular Biology, 45 (2023), 7; 5981-6002. https://doi.org/10.3390/cimb45070378
Šestan, Mario; Kifer, Nastasia; Arsov, Todor; Cook, Matthew; Ellyard, Julia; Vinuesa, Carola G.; Jelušić, Marija

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Šestan, M., Kifer, N., Arsov, T., Cook, M., Ellyard, J., Vinuesa, C. G. & Jelušić, M. (2023). The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus. Current Issues in Molecular Biology, 45. (7), 5981-6002. doi: 10.3390/cimb45070378

Šestan, Mario, et al. "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus." Current Issues in Molecular Biology, vol. 45, no. 7, 2023, pp. 5981-6002. https://doi.org/10.3390/cimb45070378

Šestan, Mario, Nastasia Kifer, Todor Arsov, Matthew Cook, Julia Ellyard, Carola G. Vinuesa and Marija Jelušić. "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus." Current Issues in Molecular Biology 45, no. 7 (2023): 5981-6002. https://doi.org/10.3390/cimb45070378

Šestan, M., et al. (2023) 'The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus', Current Issues in Molecular Biology, 45(7), pp. 5981-6002. doi: 10.3390/cimb45070378

Šestan M, Kifer N, Arsov T, Cook M, Ellyard J, Vinuesa CG, and sur.. The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus. Current Issues in Molecular Biology [Internet]. 2023 July 17 [cited 2024 October 19];45(7):5981-6002. doi: 10.3390/cimb45070378

M. Šestan, et al., "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus", Current Issues in Molecular Biology, vol. 45, no. 7, pp. 5981-6002, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:997251. [Accessed: 19 October 2024]

Metadata
Title (english)The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
AuthorMario Šestan
AuthorNastasia Kifer
AuthorTodor Arsov
AuthorMatthew Cook
AuthorJulia Ellyard
AuthorCarola G. Vinuesa
AuthorMarija Jelušić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) is complex and not fully understood. It involves three key factors: genetic risk factors, epigenetic mechanisms, and environmental triggers. Genetic factors play a significant role in the development of the disease, particularly in younger individuals. While cSLE has traditionally been considered a polygenic disease, it is now recognized that in rare cases, a single gene mutation can lead to the disease. Although these cases are uncommon, they provide valuable insights into the disease mechanism, enhance our understanding of pathogenesis and immune tolerance, and facilitate the development of targeted treatment strategies. This review aims to provide a comprehensive overview of both monogenic and polygenic SLE, emphasizing the implications of specific genes in disease pathogenesis. By conducting a thorough analysis of the genetic factors involved in SLE, we can improve our understanding of the underlying mechanisms of the disease. Furthermore, this knowledge may contribute to the identification of effective biomarkers and the selection of appropriate therapies for individuals with SLE.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCurrent Issues in Molecular Biology
Numberingvol. 45, no. 7, pp. 5981-6002
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb45070378
URN:NBNurn:nbn:hr:105:997251
Publication2023-07-17
Document URLhttps://www.mdpi.com/1467-3045/45/7/378
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-19 10:41:27