prikaz prve stranice dokumenta Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease
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Scientific paper - Original scientific paper
Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease
ACS Chemical Neuroscience, 14 (2023), 15; 2667-2682. https://doi.org/10.1021/acschemneuro.3c00223
Homolak, Jan; De Busscher, Joke; Zambrano-Lucio, Miguel; Joja, Mihovil; Virag, Davor; Babić Perhoč, Ana; Knezović, Ana; Osmanović Barilar, Jelena; Šalković-Petrišić, Melita

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Homolak, J., De Busscher, J., Zambrano Lucio, M., Joja, M., Virag, D., Babić Perhoč, A. ... Šalković Petrišić, M. (2023). Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease. ACS Chemical Neuroscience, 14. (15), 2667-2682. doi: 10.1021/acschemneuro.3c00223

Homolak, Jan, et al. "Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease." ACS Chemical Neuroscience, vol. 14, no. 15, 2023, pp. 2667-2682. https://doi.org/10.1021/acschemneuro.3c00223

Homolak, Jan, Joke De Busscher, Miguel Zambrano Lucio, Mihovil Joja, Davor Virag, Ana Babić Perhoč, Ana Knezović, Jelena Osmanović Barilar and Melita Šalković Petrišić. "Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease." ACS Chemical Neuroscience 14, no. 15 (2023): 2667-2682. https://doi.org/10.1021/acschemneuro.3c00223

Homolak, J., et al. (2023) 'Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease', ACS Chemical Neuroscience, 14(15), pp. 2667-2682. doi: 10.1021/acschemneuro.3c00223

Homolak J, De Busscher J, Zambrano Lucio M, Joja M, Virag D, Babić Perhoč A, and sur.. Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease. ACS Chemical Neuroscience [Internet]. 2023 August 02 [cited 2025 February 17];14(15):2667-2682. doi: 10.1021/acschemneuro.3c00223

J. Homolak, et al., "Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease", ACS Chemical Neuroscience, vol. 14, no. 15, pp. 2667-2682, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:161445. [Accessed: 17 February 2025]

Metadata
Title (english)Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease
AuthorJan Homolak
AuthorJoke De Busscher
AuthorMiguel Zambrano-Lucio
AuthorMihovil Joja
AuthorDavor Virag
AuthorAna Babić Perhoč
AuthorAna Knezović
AuthorJelena Osmanović Barilar
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is currently unknown whether GI alterations arise as a consequence of central nervous system (CNS) pathology or play a causal role in the pathogenesis. GI mucus is a possible mediator of GI dyshomeostasis in neurological disorders as the CNS controls mucus production and secretion via the efferent arm of the brain-gut axis. The aim was to use a brain-first model of sporadic AD induced by intracerebroventricular streptozotocin (STZ-icv; 3 mg/kg) to dissect the efferent (i.e., brain-to-gut) effects of isolated central neuropathology on the GI mucus. Morphometric analysis of goblet cell mucigen granules revealed altered GI mucus secretion in the AD model, possibly mediated by the insensitivity of AD goblet cells to neurally evoked mucosal secretion confirmed by ex vivo cholinergic stimulation of isolated duodenal rings. The dysfunctional efferent control of the GI mucus secretion results in altered biochemical composition of the mucus associated with reduced mucin glycoprotein content, aggregation, and binding capacity in vitro. Finally, functional consequences of the reduced barrier-forming capacity of the mucin-deficient AD mucus are demonstrated using the in vitro two-compartment caffeine diffusion interference model. Isolated central AD-like neuropathology results in the loss of efferent control of GI homeostasis via the brain-gut axis and is characterized by the insensitivity to neurally evoked mucosal secretion, altered mucus constitution with reduced mucin content, and reduced barrier-forming capacity, potentially increasing the susceptibility of the STZ-icv rat model of AD to GI and systemic inflammation induced by intraluminal toxins, microorganisms, and drugs.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleACS Chemical Neuroscience
Numberingvol. 14, no. 15, pp. 2667-2682
p-ISSN1948-7193
e-ISSN1948-7193
DOIhttps://doi.org/10.1021/acschemneuro.3c00223
URN:NBNurn:nbn:hr:105:161445
Publication2023-08-02
Document URLhttps://pubs.acs.org/doi/10.1021/acschemneuro.3c00223
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-25 10:59:16