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master's thesis
Eosinophilic Esophagitis
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:462250
Khan, Zmarak
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Khan, Z. (2024). Eosinophilic Esophagitis (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:462250

Khan, Zmarak. "Eosinophilic Esophagitis." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:462250

Khan, Zmarak. "Eosinophilic Esophagitis." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:462250

Khan, Z. (2024). 'Eosinophilic Esophagitis', Master's thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:462250

Khan Z. Eosinophilic Esophagitis [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:462250

Z. Khan, "Eosinophilic Esophagitis", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:462250

Metadata
TitleEosinophilic Esophagitis
Title (english)Eozinofilni ezofagitis
AuthorZmarak Khan
MentorMirjana Kalauz (mentor)
Committee memberMirjana Kalauz (predsjednik povjerenstva)
Committee memberMarija Bakula (član povjerenstva)
Committee memberSilvija Čuković-Čavka (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
There has been an extraordinary development in our understanding of eosinophilic esophagitis (EoE) over the last twenty years. This is a chronic immune system disorder that occurs when there is an increase in the numbers of eosinophils in the esophagus, leading to inflammation and symptoms such as chest pain and heartburn and most prominently, dysphagia which refers to food being stuck in the esophagus. It is usually linked to allergies such as food allergies and asthma. The diagnosis normally entails endoscopy and biopsy of the esophageal tissue for diagnosis. The treatment of this disease involves dietary control to avoid allergens, drugs like proton pump inhibitors (PPIs) or topical steroids and occasionally esophageal dilation. Initially, research focused on defining characteristics of the disease and the evaluation of its impact. Recent studies changed this tendency by identifying particular risk factors that could facilitate development of the disease. In this thesis we seek to solidify the current fundamental understandings of this disease, resulting in a comprehensive knowledge base. Furthermore, we present two in depth clinical cases, highlighting how their clinical presentations correlate with the current knowledge base of the disease. Moreover, the paper analyses different modalities of treatments effectiveness as well as implications of untimely therapy.
Abstract (croatian)
U posljednjih dvadeset godina došlo je do izvanrednog napretka u našem razumijevanju eozinofilnog ezofagitisa (EoE). EoE je kronični poremećaj imunološkog sustava koji se javlja kada se poveća broj eozinofila u jednjaku, što dovodi do upale i simptoma kao što su bol u prsima i žgaravica, a najistaknutiji simptom je disfagija, koja se odnosi na osjećaj zaglavljenosti hrane u jednjaku. EoE je obično povezan s alergijama, poput alergija na hranu i astme. Dijagnoza EoE obično uključuje endoskopiju i biopsiju tkiva jednjaka kako bi se potvrdila prisutnost eozinofila. Liječenje ove bolesti uključuje kontrolu prehrane kako bi se izbjegli alergeni, lijekove poput inhibitora protonske pumpe ili topičnih steroida te povremeno dilataciju jednjaka. U početku su istraživanja bila usmjerena na definiranje karakteristika bolesti i procjenu njenog utjecaja. Nedavne studije promijenile su taj fokus identificirajući specifične faktore rizika koji bi mogli olakšati razvoj bolesti. U ovoj tezi nastojimo učvrstiti trenutno temeljno razumijevanje ove bolesti, stvarajući sveobuhvatnu bazu znanja. Nadalje, predstavljamo dva detaljna klinička slučaja, naglašavajući kako njihovi klinički prikazi koreliraju s trenutnim saznanjima o bolesti. Osim toga, rad analizira učinkovitost različitih modaliteta liječenja kao i implikacije nepravovremenog terapijskog pristupa. Ova teza doprinosi boljem razumijevanju eozinofilnog ezofagitisa, nudeći pregled trenutnog stanja istraživanja, identificirajući ključne faktore rizika i evaluirajući učinkovitost postojećih tretmana.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:462250
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-18 07:55:14