prikaz prve stranice dokumenta Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases
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master's thesis
Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:301386
Park, Eun Joo
University of Zagreb
School of Medicine
Department of Histology and Embryology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Park, E. J. (2024). Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:301386

Park, Eun Joo. "Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:301386

Park, Eun Joo. "Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:301386

Park, E. J. (2024). 'Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases', Master's thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:301386

Park EJ. Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:301386

E. J. Park, "Overview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:301386

Metadata
TitleOverview of the results of clinical studies based on stem cell transplantation for patients suffering from nervous system diseases
Title (croatian)Pregled rezultata kliničkih studija temeljenih na transplantaciji matičnih stanica pacijentima oboljelima od bolesti živčanog sustava
AuthorEun Joo Park
MentorDinko Mitrečić (mentor)
Committee memberDinko Mitrečić (predsjednik povjerenstva)
Committee memberAnton Glasnović (član povjerenstva)
Committee memberMarina Radmilović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract
Stem cell transplantation (SCT) is a promising strategy in developing new treatments for diseases like Parkinson’s, Alzheimer’s, multiple sclerosis (MS), stroke and amyotrophic lateral sclerosis (ALS). Stem cells are undifferentiated cells with potential to develop into any needed cell type. They have the ability to regenerate damaged nerve tissue or restore nerve cell functions. Following that, stem cell transplantation has been successfully applied in clinical trials for the treatment of neurological disorders, with varying degrees of progress and success. For example, mesenchymal stem cells have been shown to improve stroke outcomes by restoring blood flow, removing intracranial blood clots and reducing intracranial pressure. On the other hand, human neural stem cells can increase the degree of neuroregeneration, while autologous CD-34 positive hematopoietic stem cells can improve outcomes in patients with MS. Finally, neural stem cells (NSCs) can be used to treat MS by re-establishing functional interactions between neural and glial cells or by activating endogenous neural cells. In addition to positive effects observed in clinical trials, this thesis also reviews possible drawbacks and points towards elements which need to be improved before such protocols become routine part of therapeutic procedures.
Abstract (croatian)
Transplantacija matičnih stanica (SCT) je obećavajuća strategija u razvoju novih terapija za bolesti kao što su Parkinsonova bolest, Alzheimerova bolest, multipla skleroza (MS), moždani udar i amiotrofična lateralna skleroza (ALS). Matične stanice su nediferencirane stanice s potencijalom koji im omogućuje razviti se u bilo koju potrebnu vrstu stanica, a imaju sposobnost obnove oštećenog živčanog tkiva koju prati i obnova funkcije živčanih stanica. Transplantacija matičnih stanica uspješno je primijenjena u kliničkim ispitivanjima za liječenje neuroloških poremećaja, s različitim stupnjevima napretka i uspjeha. Na primjer, pokazalo se da mezenhimalne matične stanice poboljšavaju ishode moždanog udara obnavljanjem protoka krvi, uklanjanjem intrakranijalnih krvnih ugrušaka i smanjenjem intrakranijskog tlaka. S druge strane, ljudske živčane matične stanice mogu povećati stupanj obnove tkiva, dok autologne CD-34 pozitivne hematopoetske matične stanice mogu poboljšati ishode kod bolesnika s MS-om. Konačno, živčane matične stanice (NSC) mogu se koristiti za liječenje MS ponovnim uspostavljanjem funkcionalnih interakcija između neurona i glijalnih stanica ili aktiviranjem endogenih stanica. Osim pozitivnih učinaka uočenih u kliničkim ispitivanjima, ovaj rad razmatra i moguće nedostatke te ukazuje na elemente koje je potrebno poboljšati prije nego što takvi protokoli postanu rutinski dio terapijskih postupaka.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:301386
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-21 07:43:07