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Scientific paper - Original scientific paper
Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia
Biomolecules, 14 (2024), 3; 302. https://doi.org/10.3390/biom14030302
Španić Popovački, Ena; Vogrinc, Dora; Fuller, Heidi R.; Langer Horvat, Lea; Mayer, Davor; Kopić, Janja; Pintarić, Klara; Babić Leko, Mirjana; Pravica, Mihaela; Krsnik, Željka; Marčinko, Darko; Šagud, Marina; Hof, Patrick R.; Mladinov, Mihovil; Šimić, Goran More authors...

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Španić Popovački, E., Vogrinc, D., Fuller, H. R., Langer Horvat, L., Mayer, D., Kopić, J. ... Šimić, G. (2024). Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia. Biomolecules, 14. (3). doi: 10.3390/biom14030302

Španić Popovački, Ena, et al. "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia." Biomolecules, vol. 14, no. 3, 2024. https://doi.org/10.3390/biom14030302

Španić Popovački, Ena, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, et al. "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia." Biomolecules 14, no. 3 (2024). https://doi.org/10.3390/biom14030302

Španić Popovački, E., et al. (2024) 'Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia', Biomolecules, 14(3). doi: 10.3390/biom14030302

Španić Popovački E, Vogrinc D, Fuller HR, Langer Horvat L, Mayer D, Kopić J, and sur.. Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia. Biomolecules [Internet]. 2024 March 04 [cited 2024 November 09];14(3). doi: 10.3390/biom14030302

E. Španić Popovački, et al., "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia", Biomolecules, vol. 14, no. 3, March 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:372634. [Accessed: 09 November 2024]

Metadata
Title (english)Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia
AuthorEna Španić Popovački
AuthorDora Vogrinc
AuthorHeidi R. Fuller
AuthorLea Langer Horvat
AuthorDavor Mayer
AuthorJanja Kopić
AuthorKlara Pintarić
AuthorMirjana Babić Leko
AuthorMihaela Pravica
AuthorŽeljka Krsnik
AuthorDarko Marčinko
AuthorMarina Šagud
AuthorPatrick R. Hof
AuthorMihovil Mladinov
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Forensic Medicine
Abstract (english)
Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction. In the context of major developmental hypotheses of schizophrenia, notably those concerning maternal immune activation and neuroinflammation, we studied NLRP1 expression and content in the postmortem brain tissue of 10 schizophrenia and 10 control subjects. In the medial orbitofrontal cortex (Brodmann’s area 11/12) and dorsolateral prefrontal cortex (area 46) from both hemispheres of six schizophrenia subjects, the NLRP1 mRNA expression was significantly higher than in six control brains (p < 0.05). As the expression difference was highest for the medial orbitofrontal cortex in the right hemisphere, we assessed NLRP1-immunoreactive pyramidal neurons in layers III, V, and VI in the medial orbitofrontal cortex in the right hemisphere of seven schizophrenia and five control brains. Compared to controls, we quantified a significantly higher number of NLRP1-positive pyramidal neurons in the schizophrenia brains (p < 0.01), suggesting NLRP1 inflammasome activation in schizophrenia subjects. Layer III pyramidal neuron dysfunction aligns with working memory deficits, while impairments of pyramidal neurons in layers V and VI likely disrupt predictive processing. We propose NLRP1 inflammasome as a potential biomarker and therapeutic target in schizophrenia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 14, no. 3, 302
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom14030302
URN:NBNurn:nbn:hr:105:372634
Publication2024-03-04
ProjectNumber: IP-2019-04-3584
Title (croatian): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Title (english): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Acronym: ALZ-BBB-INNATETAU
Leader: Goran Šimić
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: KK.01.1.1.01.0007
Title (croatian): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Title (english): .
Acronym: ZCI Neuro
Leader: Miloš Judaš
Jurisdiction: eu
Funding stream: European Regional Development Fund
Document URLhttps://www.mdpi.com/2218-273X/14/3/302
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-22 07:30:33