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Scientific paper - Original scientific paper
In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes
Biomedicines, 12 (2024), 2; 381. https://doi.org/10.3390/biomedicines12020381
Bulum, Tomislav; Brkljačić, Neva; Tičinović Ivančić, Angelika; Čavlović, Maja; Prkačin, Ingrid; Tomić, Martina

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bulum, T., Brkljačić, N., Tičinović Ivančić, A., Čavlović, M., Prkačin, I. & Tomić, M. (2024). In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes. Biomedicines, 12. (2). doi: 10.3390/biomedicines12020381

Bulum, Tomislav, et al. "In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes." Biomedicines, vol. 12, no. 2, 2024. https://doi.org/10.3390/biomedicines12020381

Bulum, Tomislav, Neva Brkljačić, Angelika Tičinović Ivančić, Maja Čavlović, Ingrid Prkačin and Martina Tomić. "In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes." Biomedicines 12, no. 2 (2024). https://doi.org/10.3390/biomedicines12020381

Bulum, T., et al. (2024) 'In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes', Biomedicines, 12(2). doi: 10.3390/biomedicines12020381

Bulum T, Brkljačić N, Tičinović Ivančić A, Čavlović M, Prkačin I, Tomić M. In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes. Biomedicines [Internet]. 2024 February 07 [cited 2024 November 26];12(2). doi: 10.3390/biomedicines12020381

T. Bulum, N. Brkljačić, A. Tičinović Ivančić, M. Čavlović, I. Prkačin and M. Tomić, "In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes", Biomedicines, vol. 12, no. 2, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:542841. [Accessed: 26 November 2024]

Metadata
Title (english)In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes
AuthorTomislav Bulum
AuthorNeva Brkljačić
AuthorAngelika Tičinović Ivančić
AuthorMaja Čavlović
AuthorIngrid Prkačin
AuthorMartina Tomić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Type 2 diabetes mellitus (T2DM) significantly increases the risk of peripheral artery disease (PAD), and diabetes is the leading cause of nontraumatic amputations. This study investigated the risk factors for transcutaneous oxygen pressure (TcPO2) in T2DM, a noninvasive method to quantify skin oxygenation and the underlying microvascular circulation. The study included 119 T2DM patients (91 male/28 female). TcPO2 measurements were conducted with the Tina TCM4 Series transcutaneous monitor (Radiometer, Copenhagen, Sweden) and skin electrodes. Patients with TcPO2 < 40 mmHg were younger (p = 0.001), had significantly higher systolic blood pressure (SBP) (p = 0.023), glycated hemoglobin (HbA1c) (p = 0.013), fasting plasma glucose (fPG) (p = 0.038), total cholesterol (p = 0.006), LDL cholesterol (p = 0.004), and had more frequent smoking habits (p = 0.001) than those with TcPO2 ≥ 40 mmHg. The main predictors for the TcPO2 value (R2 = 0.211) obtained via stepwise regression analysis were age, smoking, SBP, HbA1c, fPG, and total and LDL cholesterol. Among all the listed predictors, smoking, HbA1c, and LDL cholesterol were found to be the most significant, with negative parameter estimates of −3.051310 (p = 0.0007), −2.032018 (p = 0.0003), and −2.560353 (p = 0.0046). The results of our study suggest that in association with other risk factors, smoking is the main predictor for lower TcPO2 in T2DM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 2, 381
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12020381
URN:NBNurn:nbn:hr:105:542841
Publication2024-02-07
Document URLhttps://www.mdpi.com/2227-9059/12/2/381
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-13 14:47:57