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Scientific paper - Original scientific paper
Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period
Antibiotics, 13 (2024), 2; 118. https://doi.org/10.3390/antibiotics13020118
Predavec, Nina; Perčinić, Antonio; Herljević, Zoran; Rezo Vranješ, Violeta; Pavlović, Maja; Šalek, Zrinko; Kuliš, Tomislav; Bilić, Ernest; Mareković, Ivana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Predavec, N., Perčinić, A., Herljević, Z., Rezo Vranješ, V., Pavlović, M., Šalek, Z. ... Mareković, I. (2024). Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period. Antibiotics, 13. (2). doi: 10.3390/antibiotics13020118

Predavec, Nina, et al. "Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period." Antibiotics, vol. 13, no. 2, 2024. https://doi.org/10.3390/antibiotics13020118

Predavec, Nina, Antonio Perčinić, Zoran Herljević, Violeta Rezo Vranješ, Maja Pavlović, Zrinko Šalek, Tomislav Kuliš, Ernest Bilić and Ivana Mareković. "Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period." Antibiotics 13, no. 2 (2024). https://doi.org/10.3390/antibiotics13020118

Predavec, N., et al. (2024) 'Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period', Antibiotics, 13(2). doi: 10.3390/antibiotics13020118

Predavec N, Perčinić A, Herljević Z, Rezo Vranješ V, Pavlović M, Šalek Z, and sur.. Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period. Antibiotics [Internet]. 2024 January 25 [cited 2024 November 27];13(2). doi: 10.3390/antibiotics13020118

N. Predavec, et al., "Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period", Antibiotics, vol. 13, no. 2, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:352981. [Accessed: 27 November 2024]

Metadata
Title (english)Bacteriuria in Paediatric Oncology Patients: Clinical Features, Distribution and Antimicrobial Susceptibility of Bacterial Pathogens at University Hospital Centre Zagreb, Croatia over a 4-Year Period
AuthorNina Predavec
AuthorAntonio Perčinić
AuthorZoran Herljević
AuthorVioleta Rezo Vranješ
AuthorMaja Pavlović
AuthorZrinko Šalek
AuthorTomislav Kuliš
AuthorErnest Bilić
AuthorIvana Mareković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
Bacteriuria in paediatric oncology patients have not been well studied. This retrospective study analysed clinical features, distribution and antimicrobial susceptibility of bacterial pathogens cultured from urine in paediatric oncology patients over a 4-year period (2019–2022). A total of 143 episodes of bacteriuria were documented in 74 patients. Neutropenia was present in 17.5% (25/143), symptoms in 25.9% (37/143) and urinary catheter in 7.0% (10/143) episodes. Symptomatic bacteriuria episodes were statistically significantly more frequent in patients with neutropenia (p = 0.0232). The most common bacterial pathogens were Escherichia coli (n = 49; 32.2%), Klebsiella spp. (n = 34; 22.4%), Pseudomonas aeruginosa (n = 22; 14.5%) and Enterococcus spp. (n = 21; 13.8%). Extended-spectrum β-lactamases-producing (ESBL) Enterobacterales were found in 11 episodes (11/143; 7.7%) with the highest proportion among Klebsiella pneumoniae isolates (n = 7/34; 20.6%). No carbapenem-resistant Enterobacterales, multidrug-resistant P. aeruginosa or vancomycin-resistant Enterococcus spp. were found. The most important novelties are demonstrating P. aeruginosa as one of the prominent bacteriuria pathogens in this patient population, presence of ESBL isolates and carbapenem-resistant P. aeruginosa later during hospitalization highlights the need for appropriate antimicrobial treatment. However, because of the small number of symptomatic patients, further studies are needed to clarify the importance of including urine culture in the diagnostic process in patients with febrile neutropenia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntibiotics
Numberingvol. 13, no. 2, 118
e-ISSN2079-6382
DOIhttps://doi.org/10.3390/antibiotics13020118
URN:NBNurn:nbn:hr:105:352981
Publication2024-01-25
Document URLhttps://www.mdpi.com/2079-6382/13/2/118
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-25 10:08:20