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master's thesis
Etiologija encefalitisa u djece i adolescenata
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:476255
Čučić, Ana
University of Zagreb
School of Medicine
Department of Infectious Diseases

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Čučić, A. (2016). Etiologija encefalitisa u djece i adolescenata (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:476255

Čučić, Ana. "Etiologija encefalitisa u djece i adolescenata." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:476255

Čučić, Ana. "Etiologija encefalitisa u djece i adolescenata." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:476255

Čučić, A. (2016). 'Etiologija encefalitisa u djece i adolescenata', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:476255

Čučić A. Etiologija encefalitisa u djece i adolescenata [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:476255

A. Čučić, "Etiologija encefalitisa u djece i adolescenata", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:476255

Metadata
TitleEtiologija encefalitisa u djece i adolescenata
Title (english)Etiology of encephalitis in children and adolescents
AuthorAna Čučić
MentorGoran Tešović (mentor)
Committee memberJosip Begovac (predsjednik povjerenstva)
Committee memberMarija Santini (član povjerenstva)
Committee memberGoran Tešović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Zagreb
Defense date and country2016-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Encefalitis je upalni proces koji zahvaća moždani parenhim i posljedično dovodi do poremećaja moždane funkcije. U većini slučajeva upalni proces istodobno zahvaća i moždane ovojnice i tada govorimo o meningoencefalitisu. Prema etiologiji dijelimo ih na infektivne (primarne) i postinfektivne, u koje se ubrajaju i postvakcinalni, te autoimuni encefalitisi. Među infektivnim encefalitisima najčešći uzročnici su virusi i to herpes simplex virus (HSV) tip 1 i 2, nonpolio enterovirusi (NPEV), te arbovirusi (virusi koje prenose člankonožci). Iako je poznato više od 100 uzročnika akutnog encefalitisa više od 60% slučajeva ostane etiološki nedokazano. Autoimune encefalopatije etiološki se mogu podijeliti u paraneoplastične i ne paraneoplastične. Simptomi i znakovi autoimunog encefalitisa najčešće uključuju glavobolju, promjene u ponašanju, poremećaje pamćenja, poremećaje spavanja, epileptičke napadaje pa čak i poremećaje svijesti. Kod odraslih češće su autoimune encefalopatije paraneoplastićne etiologije, uzrokovane protutijelima na intracelularne antigene (Ma2, Hu) koje slabo reagiraju na imunoterapiju. Kod djece i adolescenata češći su encefalitisi uzrokovani protutijelima na površinske, odnosno sinaptičke antigene (NMDAR). U ovom radu prikazana je etiologija encefalitisa, te analiza podataka prikupljenih na 83 bolesnika koja su se liječila u Klinici za infektivne bolesti „Dr. Fran Mihaljević“ u periodu od 1.1.2011. do 31.12.2015. godine pod tom dijagnozom. Rezultati dobiveni ovim istraživanjem uspoređeni su s prethodnom studijom koja je analizirala etiologiju encefalitisa u djece i adolescenata u razdoblju 2000. – 2010. U odnosu na prethodno razdoblje razvidan je porast broja bolesnika s etiološki utvrđenom dijagnozom.
Abstract (english)
Encephalitis is a brain parenchyma inflammation leading to the impairment of brain function. In majority of cases, inflammation concurrently spreads to brain membranes, leading to meningoencephalitis. The encephalitis can be due to its etiology categorized into infectious (primary), post-infectious (which includes post-vaccinal), and autoimmune. Viral infections, primarily herpes simplex virus (HSV) 1 and 2, non-polio enteroviruses, and arboviruses (arthropod borne) are the most common causes of infectious encephalitis. Although more than 100 infectious agents can cause acute encephalitis, in only 60% of cases the underlying etiology is identified. Etiology of autoimmune encephalopathies can be divided into paraneoplastic and non-paraneoplastic. Symptoms and signs of autoimmune encephalitis commonly include headache, behavioral changes, memory and sleep disturbances, seizures, and impaired consciousness. In adults, the autoimmune encephalopathies are most commonly paraneoplastic in nature and respond poorly to the immunosuppressive therapy. In children and adolescents, autoimmune encephalopathies are more commonly caused by autoantibodies targeting surface or synapse antigens (NMDAR). This thesis reviews the encephalitis etiology and presents the data on 83 with encephalitis treated at the University Hospital for Infectious Diseases “Dr. Fran Mihaljević” from January 1, 2011 to December 31, 2015. Results were compared to previouus data obtained from study covering 11-years period (2000 – 2010). Significantly difference in the number of etiologycaly confirmed cases were found.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:476255
Study programmeTitle: Studies in Nursing
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-03-17 08:26:01