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doctoral thesis
Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:003984
Misir, Zvonimir
University of Zagreb
School of Medicine
Department of Pathology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Misir, Z. (2024). Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:003984

Misir, Zvonimir. "Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:003984

Misir, Zvonimir. "Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:003984

Misir, Z. (2024). 'Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih', Doctoral thesis, University of Zagreb, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:003984

Misir Z. Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:105:003984

Z. Misir, "Imunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:003984

Metadata
TitleImunohistokemijska izraženost proteina MAGE-A10 i NY-ESO-1 u primarnom adenokarcinomu želuca s metastazama u regionalne limfne čvorove i bez njih
Title (english)Immunohistochemical expression of MAGE-A10 and NY-ESO-1 proteins in primary gastric adenocarcinoma with and without regional lymph nodes metastases
AuthorZvonimir Misir
MentorMonika Ulamec (mentor)
Committee memberDavor Tomas (predsjednik povjerenstva)
Committee memberIvica Grgurević (član povjerenstva)
Committee memberAna Katušić Bojanac (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pathology)
Zagreb
Defense date and country2024-12-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Karcinom želuca (GC) multifaktorijalna je bolest na koju utječu okolišni i genetski čimbenici. Sve više dokaza ukazuje na to da tumor-testis antigeni (CTA) igraju ključnu ulogu u metastatskom potencijalu raznih tumora. Nekoliko je studija povezalo izraženost CTA s većim metastatskim potencijalom i slabim odgovorom na kemoterapiju. Antigeni NY-ESO-1 i MAGE-A10 izraženi su u tumorskim tkivima, dok je njihova izraženost u normalnim tkivima ograničena na spermatogonije. Ova studija imala je za cilj odrediti izraženost NY-ESO-1 i MAGE-A10 proteina u primarnom adenokarcinomu želuca i usporediti je s nodalnim statusom, TNM stadijem, dobi, spolom i preživljenjem. Analizirali smo uzorke adenokarcinoma želuca 53 bolesnika s negativnim i 55 bolesnika s pozitivnim limfnim čvorovima na izraženost NY-ESO-1 i MAGE-A10 antigena koristeći imunohistokemijski test. Bolesnici s pozitivnom izraženošću NY-ESO-1 u primarnim tumorima imali su medijan preživljenja od 19,0 mjeseci (raspon 14,1-24,0), za razliku od onih s negativnom ekspresijom, koji su imali medijan preživljenja od 52,0 mjeseca (raspon 0,0-133,3) (chi -kvadrat 7,99, P=0,005). T status, N status i izraženost NY-ESO-1 proteina bili su neovisno povezani s kraćim preživljenjem. Antigen MAGE-A10 nije pokazao povezanost s ispitivanim kliničko-patološkim parametrima. Zaključno, naši rezultati sugeriraju da povećana izraženost NY-ESO-1 antigena potencijalno može poslužiti kao prognostički biomarker za karcinom želuca.
Abstract (english)
Gastric cancer (GC) is a multifactorial disease influenced by both environmental and genetic factors. Growing evidence suggests that cancer-testis antigens (CTAs) play a crucial role in the metastatic potential of various tumors. Several studies have linked CTA expression with higher metastatic potential, and poor chemotherapy response. NY-ESO-1 and MAGE-A10 antigens are expressed in tumor tissues, while its expression in normal tissues is restricted to spermatogonia. This study aimed to determine the expression of NY-ESO-1 and MAGE-A10 in primary adenocarcinoma of the stomach and to compare it with nodal status, TNM stage, age, gender, and survival. We analyzed GC tissue from 53 node-negative and 55 node-positive primary gastric carcinoma patients for NY-ESO-1 and MAGE-A10 expression using immunohistochemical assay. Patients with positive NY-ESO-1 expression in primary tumors had a median survival of 19.0 months (range 14.1–24.0), in contrast to those with negative expression, who had a median survival of 52.0 months (range 0.0–133.3) (chi-square 7.99, P=0.005). T status, N status, and NY-ESO-1 expression were all independently associated with shorter survival. MAGE-A10 antigen did not show association with the investigated clinicopathological parameters. In summary, our findings suggest that increased expression of NY-ESO-1 could potentially serve as a prognostic biomarker for GC.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:003984
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent92 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-12-09 12:20:17