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master's thesis
Rana proteinurija kao prediktor kronične nefropatije presatka
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:603831
Zagorec, Nikola
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Zagorec, N. (2016). Rana proteinurija kao prediktor kronične nefropatije presatka (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:603831

Zagorec, Nikola. "Rana proteinurija kao prediktor kronične nefropatije presatka." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:603831

Zagorec, Nikola. "Rana proteinurija kao prediktor kronične nefropatije presatka." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:603831

Zagorec, N. (2016). 'Rana proteinurija kao prediktor kronične nefropatije presatka', Master's thesis, University of Zagreb, School of Medicine, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:603831

Zagorec N. Rana proteinurija kao prediktor kronične nefropatije presatka [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:105:603831

N. Zagorec, "Rana proteinurija kao prediktor kronične nefropatije presatka", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:603831

Metadata
TitleRana proteinurija kao prediktor kronične nefropatije presatka
Title (english)Early proteinuria as a predictor of chronic allograft nephropathy
AuthorNikola Zagorec
MentorMladen Knotek (mentor)
Committee memberDraško Pavlović (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberMladen Knotek (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2016-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Jedan od vodećih uzroka zatajenja bubrežnog presatka su kronična nefropatija presatka koja se patohistološki manifestira intersticijskom fibozom i tubularnom atrofijom (IF/TA). Cilj rada je bio odrediti utjecaj rane proteinurije na progresiju IF/TA-e. U studiju je uključeno 75 bolesnika s transplantiranim bubregom ili bubregom i gušteračom koji su imali biopsije bubrega na dan transplantacije (Tx) i na 12 mj. te im je određivana proteinurija u periodu 1-3 mj. i 12 mj. poslije Tx. Prosječna progresija ci skora bila je 0.62±0.78, a ct skora 0.72±0.78, a prosječne vrijednosti proteinurija mjerene u razdoblju od kraja prvog do kraja trećeg mjeseca od implantacije su 0.26±0.21g/24h. U univarijantnoj analizi iznos rane proteinurije pozitivno korelira (R=0.37, p<0.001) s iznosom skora ci godinu dana po implantaciji kao i sa iznosom ct skora godinu dana po implantaciji (R=0.3, p<0.01). U multivarijatnoj analizi rana proteinurija ostaje neovisni prediktor progresije ci skora tijekom prve godine od Tx (p=0.02). AUC rane proteinurije za predikciju progresije intersticijske fibroze tijekom 1 god. od Tx je 0.7, p<0.01. Rana proteinurija je neovisan negativan prediktor progresije IF/TA-e.
Abstract (english)
One of major causes of kidney allograft failure is chronic allograft nephropathy which is manifest by interstitial fibrosis and tubular atrophy (IT/FA). Aim of study was to determine influence of early proteinuria on IT/FA progression. 75 patients with kidney and simultaneous kidney/pancreas transplantation who had kidney biopsies performed on the day of transplantation (Tx) and 12 months after and whose proteinuria was measured in period 1-3 months and 12 months after Tx were included in the study. Average ci score progression was 0.62±0.78 and ct score progression was 0.72±0.78 and average proteinuria values measured between 1 and 3 months after implantation were 0.26±0.21g/24h. Univariate analysis showed that early proteinuria positively correlates (R=0.37, p<0.001) with ci score 1 year after implantation and also with ct score 1 year after implantation (R=0.3, p<0.01). Multivariate analysis showed that early proteinuria remains independent predictor of ci score progression during first year after Tx (p=0.02). AUC of early proteinuria for prediction of interstitial fibrosis progression during 1 year after Tx is 0.7, p<0.01. Early proteinuria is independent negative predictor of IT/FA progression.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:603831
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-13 08:11:59