Introduction: Clinical approach in patients with pulmonary embolism (PE), in addition to accurate diagnosis, requires a risk stratification depending on the probability of adverse outcome in groups with high-risk, intermediate-risk and low-risk PE. Aim: To determine which of the routine laboratory test can be used in the risk stratification of patients with PE. Methods: Prospective, longitudinal, non-intervention, cohort study of 104 patients with MSCT proven PE, in period of 12 months and analysis of clinical, laboratory and electrocardiographic signs between risk groups and patient outcome. Results: According to echocardiography, the patients were divided in high-risk group (n=33, 31,7%), intermediate-risk group (n=51, 49%) and low-risk group (n=20, 19.2%). In hemodynamically stable patients, frequency of dyspnoea (p=0.021), chest pain (p=0.028) and tachycardia (p=0.001) were significantly correlated with intermediate-risk PE. Routine laboratory tests were not reliable in risk stratification, FBC (p=0.318), CRP (p=0.080), AST (p=0.179), ALT (p=0.074), CPK (p=0.889), LDH (p=0.094), although significant correlation was found for creatinine (p=0.016), glucose (p=0.002), sodium (p=0.002) and pH (p=0.016), values were within reference range. cTnT clearly distinguishes groups of hemodynamically stable patients (p=0.037). Analysis of electrocardiography shows significant correlation for sinus tachycardia (p,p*<0.001) and RBBB (p=0.0005) for all risk groups. Conclusion: The only reliable laboratory test that clearly distinguishes patients with intermediate-risk PE from low-risk PE was cardiac troponin T (cTnT).