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master's thesis
Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:739658
Premužić, Tea
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Premužić, T. (2016). Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos) (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:739658

Premužić, Tea. "Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:739658

Premužić, Tea. "Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:739658

Premužić, T. (2016). 'Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)', Master's thesis, University of Zagreb, School of Medicine, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:739658

Premužić T. Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos) [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:105:739658

T. Premužić, "Sindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:739658

Metadata
TitleSindrom preklapanja kronične opstruktivne bolesti pluća i astme (acos)
Title (english)Asthma - chronic obstructive pulmonary disease overlap syndrome
AuthorTea Premužić
MentorNeven Tudorić (mentor)
Committee memberSanja Popović-Grle (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberNeven Tudorić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2016-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Astma i kronična opstruktivna plućna bolest najčešće su kronične bolesti dišnog sustava u našoj populaciji. Astma se tipično javlja u djetinjstvu i karakterizirana je simptomima bronhalne opstrukcije: zviždanjem, piskanjem i kašljem. Opstrukcija je reverzibilna te simptomi prestaju spontano ili primjenom terapije. KOPB je bolest srednje i starije životne dobi; karakterizirana je većim ili manjim stupnjem ireverzibilne dišne opstrukcije. Progresivnog je tijeka uz razvoj sistemnih komplikacija. U određenog broja bolesnika istovremeno postoje simptomi obje bolesti, tzv. sindrom preklapanja. Sindrom preklapanja karakteriziran je varijabilnim protokom zraka dišnim putovima uz određeni stupanj ireverzibilne bronhalne opstrukcije. Neki od čimbenika rizika za nastajanje bolesti su starenje, hiperreaktivnost bronha, astma u anamnezi, izloženost duhanskom dimu (uključujući i pasivnu) i učestale infekcije dišnog sustava. Dijagnoza sindroma preklapanja postavlja se klinički na temelju anamnestičkih podataka, fizikalnog pregleda, spirometrijskog testiranja prije i nakon primjene bronhodilatatora. Promjene u bronhalnom zidu i plućnom parenhimu te analiza sputuma mogu pomoći pri postavljanju dijagnoze. Liječenje sindroma preklapanja provodi se prema smjernicama za liječenje astme i KOPB-a. Za što bolji pristup ovim bolesnicima nužno je bolje upoznati mehanizme nastajanja, međudjelovanje rizičnih čimbenika, ulogu upalnih medijatora te mogućnosti liječenja. Boljim prepoznavanjem bolesti i boljim liječenjem smanjiti će se morbiditet i mortalitet oboljelih te poboljšati kvaliteta njihovog života.
Abstract (english)
Asthma and chronic obstructive pulmonary disease (COPD) are the most common obstructive airway diseases in our population, characterised with various degrees of airflow limitation, inflammation and tissue remodeling. Asthma is an allergic disease associated with airway hyper-responsiveness that usually develops in childhood. It leads to recurrent episodes of breathlessness, wheezing, chest tightness and coughing. Generally, it has favourable prognosis and responds well to anti-inflammatory treatment. COPD is usually associated with smoking, develops in mid to later life and is characterised with incompletely reversible airflow limitation. It results in a progressive decline in lung function, poorer quality of life and premature death. Many older patients have symptomatic and pathobiological features of both diseases, resulting in an overlap syndrome. Overlap syndrome is defined by the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. Risk factors include increasing age, bronchial hyper-responsiveness, tobacco smoke exposure, asthma and lower respiratory infections. Clinical recognition of the overlap is based on inflammatory features, changes in thickness of bronchial wall, CT scans and spirometry results before and after drug administration. The problem we are facing today is the difficulty to develop precise guidelines to diagnose ACOS, distinguish different subtypes of disease and most importantly, treat these patients more efficiently. Therefore, more studies are needed for better understanding of the disease.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:739658
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-29 11:33:13