The number of liver transplant recipients has increased. Advanced surgical techniques, modern immunosuppression and better peri- and postoperative care all led to better survival rates. Increased number of procedures and longer survival has resulted in higher frequency of complications. Digestive tract diseases are part of the pathology that can be encountered in liver transplant recipients. Infections and malignant diseases are most important complications, both connected with the immunosuppressive regimen. Complications have serious impact on morbidity, allograft rejection and recipient mortality, therefore early detection and treatment is of great importance in liver transplant recipients. Endoscopy plays major role in early detection of digestive tract diseases. Pathology of the upper GI tract most often includes esophagitis, which can be infectious (CMV, Candida) or non-infectious (reflux, eosinophilic). Besides esophagitis, a number of diseases can be found, including esophageal varices, esophageal carcinoma and PTLD, which can be seen throughout the whole length of GI tract. Most frequent pathology of the lower GI tract is infectious colitis (C. difficile, CMV) and non-infectious inflammatory disease (EGID, IBD). Kaposi’s sarcoma, colorectal carcinoma and GvHD are rare. Graft - versus - host disease, visceral form of Kaposi’s sarcoma, invasive fungal infection and PTLD has high mortality rate. This paper reviews most frequent digestive tract diseases in transplant recipients, and their epidemiology, clinical presentation, diagnostic procedures, and therapy.