Multimorbidity is the simultaneous presence of multiple chronic diseases in the same patient, which may, but need not have to share a common pathophysiological mechanism. Polypharmacy means the use of a large number of medications in individual patients, commonly referring to the use of five or more drugs. Today, ageing of the population, solitary way of life of the elderly population and the progress of medical science, which leads to the successful treatment of chronic and infectious diseases, increase the prevalence of multimorbidity. Because of that, the occurrence of polypharmacy is an increasing common problem that continues to grow with the aging of the population and consequently becomes a significant additional risk for the development of multimorbidity and mortality in such patients. The use of more medications in the same patient may be associated with negative health outcomes such as drug interactions, drug – disease interaction. Furthermore, inappropriate prescribing by physicians, taking unnecessary drugs by patients, prescribing cascade can also lead to polypharmacy. The increase in the prevalence of multimorbidity in the population is associated with an increase in the number of visits to the GP (general practitioner) and the complexity of care provided to these patients. Adequate care for patients with multimorbidity in family medicine in addition to the specific knowledge, also requires from a GP careful planning of the consultation and management of patients through the different levels of health care as well as enabling patients to take responsibility for their disease. The purpose of the modern medical science and all levels of health care that provide care to patients with multimorbidity, are focused on discovery and development of effective strategies for early detection of those chronic patients who are at risk for developing multimorbidity, for preventing development of new chronic diseases and/or development of further complications of chronic diseases and resulting polypharmacy. The purpose of this review is to show risk factors for the development of multimorbidity and GP's role in caring for such patients. A further aim is to show the importance and features of polypharmacy in patients with multimorbidity, its potential effects on the health of patient and the entire health care system and rational prescribing in the elderly population.