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master's thesis
Kongenitalne deficijencije donjih ekstremiteta
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:631586
Jakopic, Silvija
University of Zagreb
School of Medicine
Department of Orthopedics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Jakopic, S. (2016). Kongenitalne deficijencije donjih ekstremiteta (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:631586

Jakopic, Silvija. "Kongenitalne deficijencije donjih ekstremiteta." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:631586

Jakopic, Silvija. "Kongenitalne deficijencije donjih ekstremiteta." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:631586

Jakopic, S. (2016). 'Kongenitalne deficijencije donjih ekstremiteta', Master's thesis, University of Zagreb, School of Medicine, accessed 30 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:631586

Jakopic S. Kongenitalne deficijencije donjih ekstremiteta [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 November 30] Available at: https://urn.nsk.hr/urn:nbn:hr:105:631586

S. Jakopic, "Kongenitalne deficijencije donjih ekstremiteta", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:631586

Metadata
TitleKongenitalne deficijencije donjih ekstremiteta
Title (english)Congenital lower limb deficiencies
AuthorSilvija Jakopic
MentorTomislav Đapić (mentor)
Committee memberIvan Bojanić (predsjednik povjerenstva)
Committee memberTomislav Meštrović (član povjerenstva)
Committee memberTomislav Đapić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Orthopedics)
Zagreb
Defense date and country2016-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract
Kongenitalne deficijencije donjih ekstremiteta ubrajaju se u skupinu vrlo rijetkih i raznolikih urođenih poremećaja. Patološki entiteti koji se ovdje ubrajaju su: kongenitalna femoralna deficijencija, fibularna hemimelija i tibijalna hemimelija. Nejednakost dužina i osovina ekstremiteta koje se povezuju uz ove entitete dovode do promjene biomehaničkih odnosa. Embrionalni rast i razvoj donjih ekstremiteta zahtijeva preciznu i kompleksnu regulaciju gena. Istraživanja na životinjama su pokazala da mutacije tih gena ili njihova abnormalna aktivnost mogu biti uzrok kongenitalnih deficijencija donjih ekstremiteta. U većini slučajeva, točan se uzrok ne poznaje. Rana dijagnoza i klasifikacija važni su u planiranju kirurškog liječenja. Pristup svakom kirurškom liječenju je individualan, a ovisi o težini kliničke slike i o nejednakosti dužina ekstremiteta nakon završetka rasta. Cilj svakog liječenja je postizanje jednakosti dužina i osovina ekstremiteta te time i normalnih anatomskih odnosa.
Abstract (english)
Congenital lower limb deficiencies are group of relatively rare, heterogeneous disorders. The pathologic entities are congenital femoral deficiency, fibular hemimelia and tibial hemimelia. The leg lenth discrepancy associated with these abnormalities can result in severe lifelong morbiditiy related to abnormal weight bearing. The development of the lower limb requires complex and precise gene interactions. Some research in animals has demonstrated that if during early formation of the limb the genes guiding the formation of that limb are activated in an abnormal order, lower limb deficiencies, can occur. In the most cases, the specific cause of a long bone deficiency is unknown. Early diagnosis and classification are imperative for appropriate management and surgical planning. Surgical managment is determined by individual case and it depends on the severity, associated anomalies and projection of growth, and leg discrepancy at maturity. The objectives of treatment are eqalization of the lower extremity lenght, leg strengthening and achievement of near normal anatomic alignment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:631586
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-10 08:30:13