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master's thesis
Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:057145
Petrović, Andreja
University of Zagreb
School of Medicine
Department of Pathology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Petrović, A. (2016). Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:057145

Petrović, Andreja. "Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:057145

Petrović, Andreja. "Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:057145

Petrović, A. (2016). 'Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone', Master's thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:057145

Petrović A. Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:057145

A. Petrović, "Utjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:057145

Metadata
TitleUtjecaj proliferacijskog biljega Ki-67 na prognozu i odabir liječenja u bolesnika s limfomom mantl (plaštene) zone
Title (english)Impact of proliferation marker Ki-67 on therapy choice and prognosis in patients with mantle cell lymphoma
AuthorAndreja Petrović
MentorIvana Ilić (mentor)
Committee memberSven Seiwerth (predsjednik povjerenstva)
Committee memberSlavko Gašparov (član povjerenstva)
Committee memberIvana Ilić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pathology)
Zagreb
Defense date and country2016-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Limfom plaštene zone je tumor limfnog tkiva koji nastaje zloćudnom pretvorbom B limfocita, te pripada skupini non-Hodgkin limfoma. To je agresivan limfom s lošom prognozom i medijanom preživljenja između 2-5 godina. Zbog njegove agresivnosti i lošeg ishoda liječenja bolesnika, bitno je odrediti prognostičke čimbenike koji nam mogu pomoći u boljem odabiru vrste liječenja te samim tim poboljšati ishod liječenja. Cilj ovog istraživanja je utvrditi povezanost proliferacijskog biljega Ki-67 s odabirom liječenja, ishodom liječenja i ishodom bolesti bolesnika s limfomom plaštene zone. Analizirani su podaci 37 bolesnika dijagnosticiranih i liječenih u Kliničkom bolničkom centru Zagreb od siječnja 2011. do prosinca 2015. godine. Analizirani su klinički čimbenici : dob, spol, klinički stadij, vrsta liječenja, odgovor na liječenje; laboratorijski: broj eritrocita, leukocita i trombocita u perifernoj krvi u vrijeme dijagnoze i koncentracija laktat dehidrogenaze u serumu. Iz patohistološkog nalaza izvađen je podatak o visini ekspresije proliferacijskog biljega Ki-67 na tumorskim stanicama. Rezultati nisu dokazali povezanost ekspresije proliferacijskog biljega Ki-67 s odabirom i ishodom liječenja kao niti ishodom bolesti. Potrebno je provesti daljnja istraživanja koja bi pomogla u izdvajanju bolesnika koje je potrebno liječiti agresivnijom terapijom što bi rezultiralo većim brojem povoljnih ishoda liječenja i boljom prognozom bolesti.
Abstract (english)
Mantle cell lymphoma is a lymphoid tissue neoplasm that arises from malignant transformation of B lymphocytes. It is a type of non-Hodgkin's lymphoma. It is an aggressive disease with the median survival being 2-5 years. Because of its high percentage of unfavorable outcomes, determining early prognostic factors would lead to a better choice of a therapy thus improving the outcome of the therapy. The aim of this study is determining the relationship of the proliferation marker Ki-67 with the choice of therapy, outcome of the therapy and outcome of the disease. We studied 37 patients diagnosed and treated at the University Hospital Centre Zagreb from January 2011 to December 2015. The analyzed factors included clinical data: age, sex, clinical stage, type of treatment and response to treatment; laboratory data: peripheral blood count of red blood cell, leukocyte and platelet as well as Lactate dehydrogenase and alkaline phosphatase level in the serum at the time of diagnosis. The data of percentage of Ki-67 positive tumor cells was found in the histopathology report. The study did not prove a relationship between the proliferation marker Ki-67 and the type of treatment nor with outcome of treatment nor outcome of the disease. Further studies are necessary for identifying the patients that require more aggressive treatment that would lead to a higher number of favorable outcomes and a better prognosis of the disease.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:057145
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-18 11:18:03