Graves' orbitopathy (also known as thyroid eye disease TED) is an autoimmune inflammatory disorder in the Graves' hyperthyroidism (GH) that affects the orbital contents. The classic clinical symptoms developed Graves' orbitopathy (GO) are periocular edema, proptosis, eyelid retraction, eye movement disorder, disturbance of the anterior segment of the eye and decrease in visual acuity. The annual incidence of Graves' orbitopathy is 16/100,000 in women and 3/100,000 in men. Of the total number of patients approximately 50% of patients developed clinically significant form of the disease, among which 15-20% require hospitalization, and about 3-5% have severe disease with compressive neuroopticopathy known as DON (Dysthyroid optic neuropathy) that sometimes requires treatment in addition to the system and urgent surgical treatment. 45% of all patients with a mild form of the disease that require only symptomatic treatment, with most important modulatory extrinsic factor for GO being smoking. Clinical studies have proven that smoking promotes the formation of GO in patients with GH, prolonged illness and reduces the effect of treatment. Given the type of stigmatizing of this disease, patients with GO have a significantly reduced quality of life and society has significant economic repercussions. The current golden standard treatment of clinically significant and severe form of the disease is immunosuppression with corticosteroids, while in recent years more and more research deals with the effect of immunomodulatory biologicals. EUGOGO (European Group on Graves' orbitopathy), which brings together a multidisciplinary group of experts from 15 European centers issued the 2015 guidelines for the diagnosis, clinical management and treatment of various forms of GO.