prikaz prve stranice dokumenta The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention
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master's thesis
The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention
Zagreb: University of Zagreb, School of Medicine, 2016. urn:nbn:hr:105:820794
Grašić, Michael John
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Grašić, M. J. (2016). The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:820794

Grašić, Michael John. "The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:820794

Grašić, Michael John. "The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention." Master's thesis, University of Zagreb, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:105:820794

Grašić, M. J. (2016). 'The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention', Master's thesis, University of Zagreb, School of Medicine, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:820794

Grašić MJ. The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2016 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:105:820794

M. J. Grašić, "The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:105:820794

Metadata
TitleThe role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention
AuthorMichael John Grašić
MentorMatias Trbušić (mentor)
Committee memberMatias Trbušić (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberVesna Degoricija (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2016-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Clopidogrel is a PY212 antiplatelet medication which was shown to reduce mortality in patients post PCI. A percentage of the population has a resultant low platelet reactivity (LPR) or high platelet reactivity (HPR) while taking Clopidogrel. There is a connection between the LPR and increased rates of bleeding events as well as a connection between HPR and increased rates of ST events. We will examine bleeding avoidant strategies (BAS) which may be implemented to reduce bleeding event in those that are at high risk. The genetic polymorphism CYP2C19 and its association with LPR and HPR will also be looked at in more depth. Lastly, included in the discussion is the risk associated with LPR and bleeding events and HPR and ST events post PCI on clopidogrel and if these events can be accurately predicted with platelet reactivity testing before they occur. By exploring the different aspects of Clopidogrel and its resultant effects on LPR or HPR post PCI, different conclusions can be postulated on the best clinical strategies.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:105:820794
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-25 09:38:39