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master's thesis
Liječenje akutnog zatajenja bubrega u starijih osoba
Zagreb: University of Zagreb, School of Medicine, 2014. urn:nbn:hr:105:698672
Gellineo, Lana
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Gellineo, L. (2014). Liječenje akutnog zatajenja bubrega u starijih osoba (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:698672

Gellineo, Lana. "Liječenje akutnog zatajenja bubrega u starijih osoba." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:698672

Gellineo, Lana. "Liječenje akutnog zatajenja bubrega u starijih osoba." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:698672

Gellineo, L. (2014). 'Liječenje akutnog zatajenja bubrega u starijih osoba', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:698672

Gellineo L. Liječenje akutnog zatajenja bubrega u starijih osoba [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2014 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:698672

L. Gellineo, "Liječenje akutnog zatajenja bubrega u starijih osoba", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:105:698672

Metadata
TitleLiječenje akutnog zatajenja bubrega u starijih osoba
Title (english)Treatment of acute kidney injury in elderly people
AuthorLana Gellineo
MentorPetar Kes (mentor)
Committee memberDraško Pavlović (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberPetar Kes (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2014-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Starenjem dolazi do degenerativnih promjena u bubregu koje povećavaju rizik od akutnog bubrežnog zatajenja (ABZ). Stariji od 80 godina su 5 puta skloniji razviti ABZ od mlađe populacije (Pascual J, Liano F 2009). U starijih od 65 godina postoji 28% manja vjerojatnost za oporavak bubrežne funkcije nakon epizode ABZ (Schmitt i sur. 2008). Općenito je zabilježen porast incidencije ABZ kao i prosječne dobi pacijenata s pojavom epizode ABZ (Turney JH i sur. 1990)( Baraldi A i sur. 1998). Većina starijih pacijenata s ABZ imaju istovremeno disfunkciju i drugih organskih sustava što povećava mortalitet ove skupine. Takvim pacijentima je često potrebna kontinuirana metoda dijalize koja donekle oponaša funkciju zdravog bubrega. Cilj ovog rada bio je istražiti odnos primjene različitih metoda dijalize i ishoda liječenja u pacijenata ≥65 godina s ABZ bez prethodne dijagnoze kroničnog bubrežnog zatajenja (KBZ) liječenog dijalizom te usporediti razultate s mlađom dobnom skupinom (18-64 godina) akutno dijaliziranih pacijenata, također bez prethodne dijagnoze KBZ. Iz BISa i Centralnog arhiva prikupljeni su podaci o dobi, dijagnozama i ishodima liječenja za akutno dijalizirane pacijente bez prethodne dijagnoze KBZ u razdoblju 2009.- 2013. godine (uključujući i 2013. g.). Iz obrazaca dijalize su prikupljeni podaci o vrsti i trajanju dijalize te komplikacijama i antikoagulantnoj terapiji. Skupinu ≥65 godina činilo je 121 pacijenata (61%) i 77 pacijenata dobi 18-64 g. (39%). U starijoj dobnoj skupini umrlo je 64 (53%), a u mlađoj dobnoj skupini 35 pacijenata (45%) (p=0.31). 125 umrlih su bili muškarci (63%), a 73 žene (37%) (p=0.88). Najmanji udio umrlih po metodi bio je kod IHD (2.2%), a najveći kod CVVHDF (21.7%) što se pripisuje dijelom broju dijaliza tim metodama i općem stanju pacijenta (p=0.007, V=0.145). Najveća učestalost komplikacija je bila kod trajanja dijalize >48 sati (54.7%) (p<0.001, V=0.267). CVVH metoda je imala najveću učestalost komplikacija (68.5%), dok IHD najmanju (13.0 %).
Abstract (english)
People >80 yrs are 5 times more prone to developing AKI than the younger population due to ageing of the kidney (Pascual J, Liano 2009). In people ≥65 yrs there is 28% less chance of kidney function recovery after an AKI episode (Schmitt et al. 2008). An increased incidence of AKI has been recorded as well as an increase in the average age of patients with AKI (Turney JH i sur. 1990)( Baraldi A i sur. 1998). The majority of older patients with AKI have a previous dysfunction in other organ systems which increases the risk of AKI. These patients benefit from CRRT which somewhat imitates the function of a healthy kidney. The aim of this study was to determine the relationship between various dialysis methods and outcomes in patients ≥65 yrs of age with AKI without a pre-existing chronic renal insufficiency (CRI) previously treated with dialysis and to compare the findings with the younger age (18-64 yrs) group with AKI. The data for age, diagnosis and tretament outcomes in patients with AKI (without previous CRI) were gathered from the Central hospital archive and the Hospital informatic system for the period 2009 - 2013 (including year 2013). Information about complications, anticoagulation therapy, duration and type of dialysis was acquired from the dialysis forms. There were 121 patients (61%) in the group aged ≥65 yrs and 77 patients (39%) in group aged 18-64 yrs. 64 patients (53%) died in the older age group and 35 patients (45%) in the younger age group (p=0.31). 125 male (63%) and 73 female (37%) patients died (p=0.88). The least proportion of deaths was in IHD group (2.2%) and the biggest was in CVVHDF group (21.7%) which can partially be attributed to the amount of patients in each group and patient's health status at the moment (p=0.007, V=0.145). The biggest proportion of complications was in dialysis lenght >48 hrs (54.7%) (p<0.001, V=0.267). The biggest proportion of complications was in the CVVH group (68.5%) while the IHD group had the least proportion (13.0%).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:698672
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2015-10-12 09:50:02