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master's thesis
Djelovanje intravenskih anestetika na moždani protok krvi
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:452178
Tripković, Marko
University of Zagreb
School of Medicine
Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Tripković, M. (2017). Djelovanje intravenskih anestetika na moždani protok krvi (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:452178

Tripković, Marko. "Djelovanje intravenskih anestetika na moždani protok krvi." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:452178

Tripković, Marko. "Djelovanje intravenskih anestetika na moždani protok krvi." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:452178

Tripković, M. (2017). 'Djelovanje intravenskih anestetika na moždani protok krvi', Master's thesis, University of Zagreb, School of Medicine, accessed 18 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:452178

Tripković M. Djelovanje intravenskih anestetika na moždani protok krvi [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 April 18] Available at: https://urn.nsk.hr/urn:nbn:hr:105:452178

M. Tripković, "Djelovanje intravenskih anestetika na moždani protok krvi", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:452178

Metadata
TitleDjelovanje intravenskih anestetika na moždani protok krvi
Title (english)The effect of intravenous anesthetics on cerebral blood flow
AuthorMarko Tripković
MentorAnte Sekulić (mentor)
Committee memberMladen Perić (predsjednik povjerenstva)
Committee memberDINKO TONKOVIĆ (član povjerenstva)
Committee memberAnte Sekulić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities)
Zagreb
Defense date and country2017-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Intensive Care
Abstract
Intravenski anestetici se danas široko primjenjuju pri anesteziološkim postupcima. Počeli su se primjenjivati sredinom 20. stoljeća, te se od tada intenzivno proučavaju. Najprije su se počeli primjenjivati barbiturati, a kasnije su se u kliničku praksu uveli benzodiazepini, etomidat, ketamin te propofol. Međusobno se razlikuju po farmakokinetici, mehanizmu djelovanja na CNS, djelovanju na druge sustave te nuspojavama. Osobina svih intravenskih anestetika je brzi nastup djelovanja, a zbog osobitosti moždanog protoka i zbog njihovog vezanja na lipide djelovanje na CNS se očituje brzim nastupom sedacije i anestezije. Djelovanje je, osim midazolama koji je predstavnik benzodiazepina kratkotrajno, jer se brzo izlučuju iz organizma te im brzo pada koncentracija u CNS-u. U svim studijama o intravenskim anesteticima posebno se istražuje učinak na moždani protok, te moguće protektivno djelovanje na CNS. Svojim učinkom na moždani metabolizam, kao i učinkom na vrijednosti krvnog tlaka smanjuju moždani protok i potrošnju kiskika u CNS-u. Iznimku od ovog učinka predstavlja ketamin, koji povećava moždani protok i vrijednosti intrakranijalnog tlaka što ograničava njegovu upotrebu kod nekih pacijenata.
Abstract (english)
Today intravenous anesthetics are in usage in many of the anesthetics procedures. They have been used since the middle of the 20th century and since then are focus of many studies. First to use were barbiturates, and later benzodiazepines, etomidate, ketamine and propofol. The differences between them are in pharmacokinetics, effects on CNS, and effects on other systems and side effects. Their main feature are rapid action, and due to the characteristics of the cerebral blood flow and their binding to lipids rapid onset of sedation and anesthesia. Their effect is shorterm besides midazolam who is a benzodiazepine, because they are rapidly excreted from the body and their concentration decreases in CNS. In every intravenous anesthetics study their is a part that deals with their influence on cerebral blood flow, and possibly their protective CNS features. With their effect on cerebral metabolism, as their effect on blood pressure they decrease cerebral blood flow and cerebral oxygen consumption. The exception is ketamine which increases cerebral blood flow and intracranial pressure that limit its usage in some patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:452178
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-10-19 09:20:00