Acromegaly is the result of excessive secretion of growth hormone after the epiphyseal plates have closed. The most common cause of this condition is the pituitary adenoma that excites growth hormone, and it mainly affects middle-aged people. Given the size of the adenomas, they are divided into microadenoma (<10mm) and macroadenoma (> 10mm). According to invasion, they are divided into noninvasive and invasive invading the cavernous sinus. Symptoms are a consequence of the growth hormone activity on the tissues, but also the compression of surrounding structures by tumor. Acromegaly is most often presented by increasing hands, feet, lips, macroglossia, and protrusion of the lower jaw. The first therapeutic line is a transsphenoidal surgery and, in the case of failure, it is treated by radiotherapy and medical therapy. The aim of this paper was to demonstrate the success of acromegaly treatment using surgical treatment as the first therapeutic line. The remission criteria included normal age-related IGF-I levels and suppression of GH <1 μg /L after oGTT. Since 2011. until 2017. 31 patient was diagnosed with acromegaly and all were included in the study. Transsphenoidal surgery was the method of choice in 96.8% of patients. Remission was achieved in 61.3% of patients. The remission was significantly higher in the subjects who had microadenoma (83.3%) than those with macroadenoma (56%). Patients with invasive tumor had even lower remission rate (52.9%). In the event of failure, other methods of treatment were used including radiotherapy, somatostatin analogs and dopamine agonists. At the last check, 90.3% of patients are in remission.Transsphenoidal surgery has proved to be an adequate first line therapy for persons with somatotropinoma and the other treatment methods can be used in the event of failure to achieving the remission through operational treatment.