prikaz prve stranice dokumenta Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji
  Download
PDF 389.81 KB
master's thesis
Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:910422
Batarilo, Vjekoslav
University of Zagreb
School of Medicine
Department of Medical Biology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Batarilo, V. (2017). Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:910422

Batarilo, Vjekoslav. "Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:910422

Batarilo, Vjekoslav. "Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:910422

Batarilo, V. (2017). 'Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:910422

Batarilo V. Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:910422

V. Batarilo, "Uloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:910422

Metadata
TitleUloga signalnog puta WNT u epitelno-mezenhimskoj tranziciji
Title (english)Role of WNT signaling pathway in epithelial-mesenchymal transition
AuthorVjekoslav Batarilo
MentorTamara Nikuševa Martić (mentor)
Committee memberFrane Paić (predsjednik povjerenstva)
Committee memberLjiljana Šerman (član povjerenstva)
Committee memberTamara Nikuševa Martić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Zagreb
Defense date and country2017-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract
Epitelno-mezenhimska tranzicija je složeni molekularni proces u kojem dolazi do tranzicije epitelnih stanica u mezenhimske stanice. Stanične promjene koje se događaju tijekom EMT su brojne, a posljedica su prestanka ekspresije gena koji reguliraju epitelni fenotip te preuzimanja transkripcijskog obrasca ekspresije gena koji upravljaju mezenhimskim fenotipom. Neke od tih promjena su prestanak ekspresije E-kadherina, gubitak intercelularnih veza i apikalno-bazolateralne orijentacije stanice itd. Mezenhimske osobine koje stanice stječu su izgled nalik miofibroblastima, pokretljivost i invazivnost, stanice počinju secernirati molekule ekstracelularnog matriksa, manje su podložne aktivaciji apoptoze itd. EMT prisutna je i u fiziološkim i u patofiziološkim procesima. Fiziološki procesi koji su u najvećoj mjeri posljedica EMT su embriogeneza i reparacija tkiva, a patofiziološki procesi u kojima EMT sudjeluju su fibrogeneza i tumorigeneza. Jedan od glavnih puteva koji su zaslužni za aktivaciju ovog staničnog programa je Wnt signalni put. To je evolucijski drevni, konzervirani put. Kategorizirana su tri glavna Wnt puta: jedan kanonski i dva nekanonska. Kod ljudi postoji 19 različitih Wnt proteina, koji su kategorizirani zbog sličnost cisteinskih ostataka na N-terminalnom kraju, a ne prema funkcijama, koje su nota bene, vrlo različite. Wnt ligand veže se za Frizzled receptore te je središnja molekula β-katenin zaslužna za biološke učinke koji se pripisuju Wnt putu. β-katenin translocira se u jezgru gdje se veže za Tcf/Lef transkripcijski faktor i potiče ekspresiju ciljnih gena.
Abstract (english)
Epithelial-mesenchymal transition is a complex molecular process in which epithelial cells transform to mesenchymal cells. Cell changes that occur during EMT are numerous due to loss of epithelial gene expression, and activation of mesenchymal gene expression. Some of those changes are downregulation of E-cadherin expression, loss of epithelial adherens junctions, loss of apical-basolateral polarity etc. Mesenchymal traits which these cells acquire are myofibroblast-like shape, motility and invasiveness, secretion of extracellular matrix, increased resistance to apoptosis etc. EMT occurs both during physiological and pathophysiological processes. Physiological processes, which are to the greatest extent consequence of EMT, are embriogenesis and tissue reparation, while pathophysiological processes in which EMT has role are fibrogenesis and tumorigenesis. One of the major signaling pathway that activates EMT is Wnt signaling pathway. It is evolutionarily ancient and conserved pathway. There are three main Wnt signaling pathway branches; a canonical Wnt pathway and two non-canonical Wnt pathways. There are nineteen distinctive Wnt proteins in humans, which are classified as Wnt based on similarity of their N-terminal cysteine residues, rather than their functions which are quite different. The Wnt ligands bind to Frizzled receptors, while the central molecule β-catenin is responsible for biological effects of Wnt pathway. β-catenin translocates to the nucleus where it binds to Tcf/Lef transcription factor and upregulates expression of target genes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:910422
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-11-23 11:17:05