Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. The term polytrauma is defined as two or more severe injuries in at least two areas of the body. At least one out of two or more injuries or the sum total of all injuries can endanger the life of the injured person. Poorly treated acute pain in polytrauma can lead to sever anatomical and physiological changes in the central nervous system and ultimately to the development of chronic pain. Untreated pain can worsen the effect of trauma on breathing, hemodynamic stability, renal and gastrointestinal function and finally it can lead to a higher incidence of complications and death. Lower morbidity and mortality rates, shorter hospital stay, earlier mobilization and better patient satisfaction are the main goal of pain management in polytraumatized patients. A thorough physical examination is extremely valuable in selecting the most appropriate pharmacological pain management method. While provision of adequate analgesia is vitally important, it is also necessary to acknowledge serious adverse effects of pain medications and weigh them against their benefits. Up to date pain management is centred around the use of multimodal analgesia techniques in which we use different classes of analgesics and different sites of analgesic administration in order to achieve topmost therapeutic effect with reduced analgesic related side effects. In multimodal analgesia, we may administer a combination of local anaesthetics and opioids epidurally or nonsteroidal anti-inflammatory drugs orally simultaneously with opioid analgesics administered by patient-controlled analgesia. Regular assessment of the patient and revision of the pain are necessary for adjusting the correct dosage of medication. Prompt and accurate pain management can lead to improved quality of patient’s life.