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master's thesis
Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:972388
Hohnjec, Anja
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Hohnjec, A. (2017). Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:972388

Hohnjec, Anja. "Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:972388

Hohnjec, Anja. "Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:972388

Hohnjec, A. (2017). 'Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva', Master's thesis, University of Zagreb, School of Medicine, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:972388

Hohnjec A. Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:105:972388

A. Hohnjec, "Značaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:972388

Metadata
TitleZnačaj EBV serološkog statusa bolesnika s upalnom bolesti crijeva
Title (english)Importance of EBV-status in inflammatory bowel disease patients
AuthorAnja Hohnjec
MentorSilvija Čuković-Čavka (mentor)
Committee memberŽeljko Krznarić (predsjednik povjerenstva)
Committee memberSlavko Gašparov (član povjerenstva)
Committee memberSilvija Čuković-Čavka (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2017-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Prevalencija Epstein-Barrovog virusa (EBV) iznosi više od 90% u odrasloj populaciji. Klinički se EBV infekcija uglavnom prezentira u obliku infektivne mononukleoze i najčešće predstavlja samoizlječivu bolest u imunokompetentnih osoba. U skupini bolesnika, koji se liječe imunosupresivnim lijekovima, primarna infekcija, a ponekad i latentna EBV- infekcija mogu rezultirati smrću ili u konačnici razvojem limfoproliferativnih bolesti. S obzirom da rezultati dosadašnjih istraživanja ukazuju na povišeni rizik razvoja infekcija i limfoproliferativnih poremećaja u bolesnika s upalnom bolesti crijeva (IBD), recentno je uvedena preporuka da se provjeri EBV serološki status u bolesnika odmah kod postavljanja dijagnoze upalne bolesti crijeva. Stoga je cilj ovog rada bio analizirati EBV serološki status u IBD bolesnika koji se liječe u Ambulanti za upalne bolesti crijeva KBC-a Zagreb i usporediti prevalenciju s rezultatima do sada objavljenih studija u drugim populacijama. Istraživanje je provedeno u 67 bolesnika s Crohnovom bolešću i 32 bolesnika s ulceroznim kolitisom. Analizirani su podaci iz bolničkog informacijskog sustava (BIS) te potom učinjena statistička obrada podataka. Prosječna životna dob bolesnika iznosila je 37,7 godina. Od ukupnog broja bolesnika 7,07% je bilo seronegativno, a najviša stopa seronegativnih bolesnika utvrđena je u dobi između 18 i 27 godina te je ona iznosila 25%. U dobnoj skupini bolesnika između 28 i 37 godina utvrđeno je još dvoje seronegativnih pacijenata, a u starijih iznad 37 godina svi bolesnici su bili EBV seropozitivni. Podaci dobiveni u ovom istraživanju u korelaciji su s podacima svjetskih istraživanja.
Abstract (english)
The Epstein-Barr virus, with a prevalence of more than 90% in the adult population and its most common clinical presentation as infectious mononucleosis, belongs to a group of self-limited diseases in immunocompetent patients. The problem occurs in immunocompromised patients, in which a primary or even latent EBV infection can result in fatal opportunistic infections or a development of lymphoproliferative disorders such as EBV lymphoma. Recent studies outlining the potential risk of developing lymphoproliferative disorders among IBD patients report about the concerning link between immunosuppression and lymphoproliferative disorders. The aim of this study was to identify the prevalence of seropositivity for the Epstein-Barr virus among IBD patients with at least one visit to the UHC Zagreb. 99 IBD patients were randomly chosen and their EBV serological status was investigated. The database of IBD patients previously followed at the UHC Zagreb was used and data analysis was performed using the MS Excel statistical software. The average age of the patients was 37.7 years. The analysis identified 67 patients with Crohn’s disease and 32 patients with ulcerative colitis, and also revealed the highest seronegativity of 25% among patients in the age group from 18 to 27 years. Two more seronegative patients were found in the age range of 28 to 37 years. The patients above the age of 37 were all seropositive. The results from this study are in correlation with those of other studies.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:972388
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-03-21 08:31:42