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master's thesis
Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:620800
Njirić, Niko
University of Zagreb
School of Medicine
Department of Surgery

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Njirić, N. (2017). Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:620800

Njirić, Niko. "Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:620800

Njirić, Niko. "Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:620800

Njirić, N. (2017). 'Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije', Master's thesis, University of Zagreb, School of Medicine, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:620800

Njirić N. Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:620800

N. Njirić, "Izostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:620800

Metadata
TitleIzostanak epileptičkih napadaja nakon selektivne amigdalohipokampektomije
Title (english)Seizure-free outcome after selective amygdalohippocampectomy
AuthorNiko Njirić
MentorGoran Mrak (mentor)
Committee memberJosip Paladino (predsjednik povjerenstva)
Committee memberTomislav Meštrović (član povjerenstva)
Committee memberGoran Mrak (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Surgery)
Zagreb
Defense date and country2017-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Epilepsija je česta neurološka bolest koja pogađa oko 0.6-1% svjetske populacije. Otprilike jedna trećina oboljelih ne uspijeva postići izostanak epileptičkih napadaja korištenjem antiepileptičkih lijekova. U takvih je bolesnika nužno provesti dijagnostičku obradu kako bi se ustanovio mogući strukturni uzrok epilepsije i farmakorezistencije. Najčešći uzrok ovakvog oblika bolesti jest mezijalna temporalna skleroza, stanje karakterizirano gubitkom piramidalnih neurona u hipokampusu. Kliničku sliku epilepsije s mezijalnim temporalnim ishodištem karakterizira pojava viscerosenzornih auri, njušnih fenomena i oroalimentarnih automatizama. Kirurške tehnike liječenja ovog stanja su mnoge, a jedna od poštednijih je selektivna amigdalohipokampektomija, kod koje se odstranjuju hipokampus, amigdala i parahipokampalni girus. U ovom radu obrađeni su podaci 76 bolesnika operiranih ovom kirurškom tehnikom putem transsilvijskog pristupa te je analiziran ishod operacijskog liječenja. U 51 (67.1%) bolesnika je postignut ishod potpunog izostanka napadaja, a smanjenje broja lijekova je postignuto u 33 (43.4%) bolesnika nakon operacije. Ovi podaci ukazuju na to da je selektivna amigdalohipokampektomija djelotvorna tehnika kirurškog liječenja epilepsije. U bolesnika s farmakorezistentnim oblikom epilepsije je nužno ovaj modalitet liječenja primijeniti što ranije, budući da se u velikom postotku slučajeva postiže izostanak epileptičkih napadaja, a samim time i bitno poboljšanje zdravstvenog stanja bolesnika te sprječavanje daljnjeg propadanja kognitivnih funkcija.
Abstract (english)
Epilepsy is a common neurological disease, affecting approximately 0.6-1% of the global population. About one-third of epilepsy patients do not achieve seizure freedom with the use of antiepileptic drugs. It is necessary to perform a diagnostic work-up in these patients, in order to determine the existence of a potential structural cause of epilepsy and pharmacoresistancy. The most common cause of this condition is mesial temporal sclerosis, characterized by a loss of piramidal cells in the hippocampus. Signs and symptoms of epilepsy with a mesial temporal lobe focus include: viscerosensory auras, olfactory phenomena and oroalimentary automatisms. There are multiple surgical techniques available for treatment of this disease. Selective amygdalohippocampectomy is one of the most sparing among them. It involves the removal of the hippocampus, amygdala and the parahippocampal gyrus. This study analyses the outcomes of 76 patients who were surgically treated with the aforementioned technique, via a transsylvian approach. Seizure freedom was achieved in 51 (67.1%) patients. A decrease in the number of antiepileptic drugs was achieved in 33 (43.4%) patients. This data suggests selective amygdalohippocampectomy is an efficient technique of surgical epilepsy treatment. It is imperative to evaluate patients with pharmacoresistant epilepsy as soon as possible, since surgery provides seizure freedom in a large percentage of cases, thereby enhancing the health of these individuals and halting further deterioration of cognitive functions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:620800
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-03-21 10:51:31