Inflammatory bowel disease is a chronic inflammatory disorder most commonly occurring in the reproductive age, in the period from 15 to 30 years of age. Female patients have a problem of family planning decision because of fear of pregnancy outcome, possible complications due to drug side-effects or complications of the underlying disease. Recent literature on the impact of diseases and drugs on pregnancy confirms that the most of drugs are safe and the effects of drugs on fertility and pregnancy outcome are positive. The course of illness during pregnancy largely depends on the disease activity at conception time and therefore is recommended to plan pregnancy in remission of the disease. Multidisciplinary monitoring of the patient is required in order to overcome the drugs that are contraindicated and to prevent possible complications during the pregnancy. Anti-TNF drugs for the treatment of inflammatory bowel diseases belong to a group of biological drugs. Anti-TNF drugs have high efficacy in achieving remission, significant potential for mucosal healing, as well as possible development of important side effects. As more and more commonly used last years, the aim of this study is to provide an overview of available anti-TNF drugs on fertility, pregnancy and pregnancy outcome. Anti-TNF drugs may be used during pregnancy, but regarding to the fact that there are monoclonal antibodies, it is recommended termination of therapy in the third trimester of pregnancy because of a possibility of placental transmission. As the effect of the anti-TNF molecule on the immune system is significant, at the infant age, up to the sixth month of the child's life, vaccination with live vaccines is not recommended.