Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children and it affects approximately 1 in 1000 children worldwide. Children with JIA have an increased risk for uveitis and as many as 10-30% of children with JIA will develop uveitis. Severe or untreated uveitis can lead to long term complications and consequences, including cataracts, glaucoma and blindness; therefore treatment is of utmost importance. Topical corticosteroids and systemic immunosuppressants have been treatment of choice, however recently biologic agents have been used. An exploration of numerous clinical trials concerning the treatment of uveitis in JIA patients is necessary to conclude what the newest gold standard treatment should be. Specifically, a comparison of immunosuppressants alone versus a combination with biologic agents should be explored to deduce which is the most beneficial for treatment and if there is a difference in extent or type of side effects. Considering the high incidence level of this illness and the potential consequences if treatment is not provided, there is great importance in reviewing multiple clinical trials and concluding what the current treatment algorithm should be. This review aims to explore the current medical treatment of JIA –associated uveitis and the effectiveness and safety of the drugs involved.