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master's thesis
Long-term consequences of polycystic ovary syndrome
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:319093
Crumbach, Monika Elisabeth
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Crumbach, M. E. (2017). Long-term consequences of polycystic ovary syndrome (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:319093

Crumbach, Monika Elisabeth. "Long-term consequences of polycystic ovary syndrome." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:319093

Crumbach, Monika Elisabeth. "Long-term consequences of polycystic ovary syndrome." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:319093

Crumbach, M. E. (2017). 'Long-term consequences of polycystic ovary syndrome', Master's thesis, University of Zagreb, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:319093

Crumbach ME. Long-term consequences of polycystic ovary syndrome [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:105:319093

M. E. Crumbach, "Long-term consequences of polycystic ovary syndrome", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:319093

Metadata
TitleLong-term consequences of polycystic ovary syndrome
Title (croatian)Dugoročne posljedice sindroma policističnih jajnika
AuthorMonika Elisabeth Crumbach
MentorLana Škrgatić (mentor)
Committee memberLana Škrgatić (predsjednik povjerenstva)
Committee memberMiro Kasum (član povjerenstva)
Committee memberDinka Pavičić-Baldani (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2017-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It shares many features with the metabolic syndrome (insulin resistance, an increase in body mass index, changes in lipidogram, increases in C-reactive protein due to chronic inflammation). As a long-term consequence, development of cardiovascular disease (CVD) is likely. The purpose of this retrospective observational study was to explore if cardiometabolic risk factors (BMI, HOMA-IR, total cholesterol, TG, LDL-C, HDL-C, CRP) worsen over time in PCOS patients. The data of 36 PCOS patients aged 26.5 ± 6.4, in whom the diagnosis was made according to the Rotterdam criteria, was included in the study. The metabolic parameters were taken from hospital records of University Hospital Petrova Gynecological Clinic in Zagreb, Croatia. We included laboratory values measured at the starting point of the study, in 2007, and after nine years, in 2016. No significant worsening of cardiometabolic risk factors was found after the nine years. Only the percentage of PCOS patients with a BMI > 25 increased from 25.0% to 33.3% (P = 0.002). Further studies should be conducted with a larger sample size and longer duration of observation.
Abstract (croatian)
Sindrom policističnih jajnika (PCOS) najčešći je endokrinološki poremećaj u žena reprodukcijske dobi. Ovaj sindrom dijeli mnoge karakteristike metaboličkog sindroma poput inzulinske rezistencije, povišenog indeksa tjelesne mase, poremećaja vrijednosti lipida te povišenih vrijednosti C-reaktivnog proteina. S obzirom da ovi rizični metabolički parametri često prate PCOS, očekivana je veća vjerojatnost neželjenih kardiovaskularnih događaja kao dugoročna posljedica PCOS-a. Cilj je ove retrospektivne opservacijske studije bio istražiti dolazi li tijekom vremena do pogoršanja kardiometaboličkih rizičnih čimbenika (BMI, HOMA-IR, ukupni kolesterol, trigliceridi, LDL-C, HDL-C,CRP). Analizirani su podaci 36 bolesnica, prosječne dobi 26.5 ± 6.4, kod kojih je dijagnoza PCOS-a postavljena prema Rotterdamskim kriterijima 2007 godine. Podaci o vrijednostima različitih metaboličkih parametara analizirani su iz bolničkog informacijskog sustava Klinike za ženske bolesti i porode KBC-a i Medicinskog fakulteta Sveučilišta u Zagrebu. U analizu smo uključili one laboratorijske nalaze koji su izrađeni 2007. godine i ponovno 2016., odnosno nakon vremenskog intervala od devet godina. Nije nađeno značajno pogoršanje kardiometaboličkih rizičnih čimbenika u periodu od devet godina. Zabilježeno je povećanje udjela pacijentica s ITM > 25 kg/m2 (P = 0.002). Potrebne su daljnje studije koje će uključiti veći broj bolesnica s PCOS-om s dužim vremenskim periodom praćenja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:319093
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-19 08:27:34