In today’s world, social networks, also referred to as Web 2.0, have an undeniable and immeasurable influence on the lives of all people. Therefore, it is not surprising that even physicians can not resist that trend and influence, whereby their function and responsibility underwent the change in society. The increased use of social networks that has grown exponentially in the last few years has blurred the lines between physician’s personal and professional lives and it presents a new challenge that physicians must face in this informatics era. Medical professionalism that commits a physician to respect social cues that he is led by at work is a belief system about how best to organize and deliver health care, and calls on group members to jointly declare what the public and individual patients can expect regarding shared competency standards and ethical values, and to implement trustworthy means to ensure that all medical professionals live up to these promises. Because of the influence that social media have on physicians, there was a need to implement new terminology called „E-professionalism“ that is defined as the attitudes and behaviors reflecting traditional professional paradigms, but manifested through digital media. Because of the numerous benefits and disadvantages of social networks in the world of medical professionalism, it is necessary for physicians to adapt to them. Although it is known that it is a difficult task to separate personal and professional boundaries, it is very important to be transparent and to clearly establish the objectives and use of the services when engaged in social networks as a professional.