prikaz prve stranice dokumenta Imunološke karakteristike kronične opstruktivne plućne bolesti
  Download
PDF 621.82 KB
master's thesis
Imunološke karakteristike kronične opstruktivne plućne bolesti
Zagreb: University of Zagreb, School of Medicine, 2018. urn:nbn:hr:105:413208
Nedeljković, Vanja
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Nedeljković, V. (2018). Imunološke karakteristike kronične opstruktivne plućne bolesti (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:413208

Nedeljković, Vanja. "Imunološke karakteristike kronične opstruktivne plućne bolesti." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:413208

Nedeljković, Vanja. "Imunološke karakteristike kronične opstruktivne plućne bolesti." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:413208

Nedeljković, V. (2018). 'Imunološke karakteristike kronične opstruktivne plućne bolesti', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:413208

Nedeljković V. Imunološke karakteristike kronične opstruktivne plućne bolesti [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:413208

V. Nedeljković, "Imunološke karakteristike kronične opstruktivne plućne bolesti", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:105:413208

Metadata
TitleImunološke karakteristike kronične opstruktivne plućne bolesti
Title (english)Immunological aspects of chronic obstructive pulmonary disease
AuthorVanja Nedeljković
MentorMiroslav Samaržija (mentor)
Committee memberAndrea Vukić Dugac (predsjednik povjerenstva)
Committee memberMarko Jakopović (član povjerenstva)
Committee memberMiroslav Samaržija (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Abstract
Incidencija kronične opstruktivne plućne bolesti (KOPB) je u porastu i smatra se trećim vodećim uzrokom smrtnosti u svijetu što predstavlja globalni zdravstveni problem. U većini slučajeva uzrokovana je djelovanjem štetnih sastavnica cigaretnog dima, a karakterizira ju djelomično reverzibilna, ali progresivna opstrukcija dišnih putova koja se pogoršava egzacerbacijama. Strukturne i upalne stanice urođene i stečene imunosti u respiratornom traktu na cigaretni dim i druge iritanse reagiraju oslobađanjem medijatora upale kao što su IL1, IL6, IL8 i TNFα koji regrutiraju dodatne upalne stanice kao CD8+ i CD4+ T stanice, te orkestriraju urođenim i stečenim imunosnim reakcijama. KOPB je obilježen opsežnom imunosnom disfunkcijom koja dovodi do egzacerbacija i progresije bolesti, a posljedično i smanjenju kvalitete života.
Abstract (english)
The incidence of chronic obstructive pulmonary disease (COPD) is in increase and is considered to be the third leading cause of death worldwide, representing a global health problem. Most common cause of COPD is cigarette smoke, and is characterized by its partially reversible but progressive obstruction of the respiratory tract that aggravates exacerbations. Structural and inflammatory cells of innate and adaptive immune responses in the respiratory tract, react to cigarette smoke and other irritants, by releasing inflammatory mediators such as IL1, IL6, IL8 and TNFα which recruit additional inflammatory cells such as CD8 + and CD4 + T cells, and orchestrate innate and adaptive immune responses. COPD is characterized by extensive immune dysfunction which leads to exacerbation and progression of the disease, and consequently to the reduction of the quality of life.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:413208
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-27 08:05:17