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master's thesis
Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom
Zagreb: University of Zagreb, School of Medicine, 2018. urn:nbn:hr:105:643421
Paskojević, Karla
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Paskojević, K. (2018). Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:643421

Paskojević, Karla. "Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:643421

Paskojević, Karla. "Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:643421

Paskojević, K. (2018). 'Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:643421

Paskojević K. Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:643421

K. Paskojević, "Povrat glomerulonefritisa u bolesnika s transplantiranim bubregom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:105:643421

Metadata
TitlePovrat glomerulonefritisa u bolesnika s transplantiranim bubregom
Title (english)Recurrent glomerulonephritis in kidney transplant patients
AuthorKarla Paskojević
MentorIvana Vuković Brinar (mentor)
Committee memberBojan Jelaković (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberIvana Vuković Brinar (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Glomerulonefritisi (GN) su treći po učestalosti uzrok terminalnog zatajenja bubrežne funkcije dok je transplantacija metoda izbora u nadomještanju bubrežne funkcije (NBF). Kod transplantiranih bolesnika postoji rizik povrata osnovne bolesti za koji se smatra da je jedan od važnijih uzroka gubitka funkcije presatka. Cilj ovog istraživanja je ustanoviti utjecaj glomerularne bolest kao primarne bolesti nativnih bubrega, kao i samog povrata osnovne bolesti, na ishod transplantacije i petogodišnje preživljenje presatka. Retrospektivno smo analizirali 120 bolesnika s biopsijom potvrđenim GN koji su transplantirani u razdoblju od 2007. do 2012. IgA nefropatija (IgAN), fokalna segmentalna glomeruloskleroza (FSGS) i membranoproliferativni glomerulonefritis (MPGN) su predstavljali 75% podtipova GN. Sumnju na povrat bolesti smo definirali proteinurijom > 1g, dok je sam povratak potvrđen biopsijom. Izolirani povrat osnovne bolesti je dokazan u 75% bolesnika od kojih je najčešći i najznačajniji povrat bolesti bio uslijed MPGN-a (44% patohistološki dokazanih povrata). U 25% ispitanika s povratom MPGN došlo je do gubitka funkcije presatka definiranog potrebom za NBF. Udio povrata FSGS-a iznosio je 33,3% patohistološki dokazanih povrata, te u ni jednom slučaju nije došlo do gubitka funkcije presatka. Povrat IgAN je dijagnosticiran u 1 bolesnika (11,1%), kao i lupus nefritis (11,1%) kod kojeg je došlo do gubitka funkcije presatka. Funkcionalan presadak nakon petogodišnjeg praćenja imalo je 70% bolesnika, dok je gubitak funkcije presatka ili graftektomija uslijedila kod 18 bolesnika (15%), od kojih su 2 (11,1%) imala povrat osnovne bolesti. Glomerulonefritisi kao primarna bolest nativnih bubrega kao i sam povrat osnovne bolesti, nemaju negativan utjecaj na ishod transplantacije i dugoročno preživljenje presatka.
Abstract (english)
Glomerulonephritis (GN) is the third most common cause of end-stage kidney failure while the transplantation is a method of choice for renal replacement therapy. Transplant patients have a risk of recurrent GN which is considered to be an important cause of allograft loss. The aim of this study was to determine the effect of glomerular disease as a primary disease in native kidneys, as well as recurrence, on transplantation outcome and five-year allograft survival. We have retrospectively analyzed 120 patients with biopsy-proven glomerulonephritis, that have received a renal transplant from 2007 through 2012. IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS) and membranoproliferative glomerulonephritis (GN) represented 75% of GN subtypes. Recurrence suspicion was defined as proteinuria >1g while the recurrence itself was confirmed by biopsy. Isolated recurrence was proved in 7,5% patients while the most common and significant recurrence was due to MPGN (44% of biopsy-proven GN). Allograft loss, defined as a need for renal replacement therapy, was found in 25% of patients with recurrent MPGN. Recurrent FSGS occurred in 33,3% of biopsy-proven recurrences, and none of the allografts was lost. IgAN recurrence was diagnosed in one patient (11,1%), as well as lupus nephritis (11,1%) which resulted in allograft loss. Functional allograft after five-year follow up was found in 70% of patients while the allograft loss or graftectomy occurred in 18 patients (15%), of whom 2 (11,1%) had a recurrence. Glomerulonephritis as a primary disease in native kidneys, as well as recurrence, don’t have a negative impact on transplantation outcome and long-term allograft survival.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:643421
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-01-10 10:20:16