Over the past few decades, incidence of gastric cancer slowly decreases, but unfortunately its mortality rates have remained relatively unchanged. Gastric cancer continues to be one of the leading causes of cancer related death. In Croatia, gastric cancer is the third most common malignancy, while worldwide incidence is highest in Japan, Eastern Asia, South America, and Eastern Europe. Stomach cancer is more common in men than in women and rates in people over the age of 50. The risk factors linked to stomach cancer include conditions such as chronic gastritis, stomach polyps, smoking, positive family history, diet with lot of salted, smoked and canned food, poor with fresh vegetables and fruits. Most gastric cancers occur sporadically, whereas 10% has an inherited familial component. An important development in the epidemiology of gastric carcinoma has been the recognition of the association with Helicobacter pylori infection. The most common type of stomach cancer is adenocarcinoma. The Lauren classification divides gastric cancer into 2 major histologic types: intestinal or diffuse and nowadays stays most commonly used histological classification. Gastric carcinoma often remains asimptomatical while it is surgically curable. Consequently, 90% of patients with gastric cancer present with locally advanced or metastatic tumors that have poor rates of resectability. Patients may present with anorexia, weight loss and abdominal pain. Nausea, vomiting, and early satiety may occur with bulky tumors that obstruct the gastrointestinal lumen. Ulcerated tumors may cause bleeding that manifest as hematemesis, melena, or massive upper gastrointestinal hemorrhage. Endoscopy is regarded as the most sensitive and specific diagnostic method, although the CT, MRI and radiographic contrast examinations are also being used. Before gastric cancer therapy, staging must be defined by TNM (tumor, node, metastasis) classification. Choice of surgical procedure in resectable stomach cancer is dictated by size, location, and ability to achieve surgical margins free of microscopic disease. In general, curative therapy involves surgical resection, most commonly a total or subtotal gastrectomy, with an accompanying lymphadenectomy. Extended or limited lymphadenectomy remains the procedure of choice in specialized centers,although D2 dissection remains recomended standard. Patients with lymph node involvement, which is statistically a significant predictor of survival, can be treated with adjuvant therapy such as chemotherapy, chemoradiotherapy, radiation, or immunotherapy, in hope to improve results. If there is presence of ascites as a result of massive metastasis patient is declared inoperable. Those patients are given palliative therapy to improve the quality of life and release the pain. The prognosis of stomach cancer is generally poor, due to the fact the tumour has often metastasied by the time of discovery.