| Abstract | UVOD: Cilj ovog istraživanja bio je proučiti moguću ulogu video head impulse testa (vHIT) u otkrivanju lezija moždanog debla u bolesnika oboljelih od multiple skleroze (MS). ----- METODE: Uključeno je šezdeset osam ispitanika, koje smo podijelili u dvije skupine: 39 zdravih ispitanika (ZK) (78 ušiju, 20 žena, srednja dob 25,3±6,3 godina) i 29 bolesnika oboljelih od MS-a (58 ušiju, 14 žena, srednja dob 33,7±7,7 godina). vHIT je napravljen u obje skupine, te su u skupini oboljelih od MS-a analizirani nalazi MR-a u potrazi za lezijama moždanog debla. Patološki vHIT je definiran kao prisutnost overt sakada (< 200 ms) ili gain manji od 0,8 za lateralne kanale, a za prednje i stražnje kanale kao prisutnost overt sakada (< 200 ms) ili slope manji od 0,7. ----- REZULTATI: U ZK skupini nađen je sniženi gain u lateralnim kanalima u 8 od 78 ušiju (11%), nasuprot tome, u MS skupini je patološke rezultate imalo 16 od 58 ušiju (38%). Srednja vrijednost gain-a lateralnih kanala (60 ms) bila je značajno manja u MS skupini u usporedbi sa ZK skupinom (0,874±0,143 i 0,954±0,170, p=0,004). Overt sakade < 200 ms u lateralnim kanalima (p=0,018) i u stražnjima kanalima (p=0,011), overt sakade > 200 ms u lateralnim (p<0,001), prednjim (p=0,019) i stražnjim kanalima (p=0,009), i covert sakade u prednjim (p=0,042) i stražnjim kanalima (p=0,046) češće su se pojavljivale u MS skupini. Pronađena je statistički značajna povezanost između prisutnosti lezija moždanog debla vidljivih na MR-u i obostrano patološkog nalaza vHIT-a lateralnih kanala (χ(1)=3,982, p=0,046). ----- ZAKLJUČAK: Ovi rezultati upućuju da vHIT može otkriti disfunkciju moždanog debla u bolesnika oboljelih od MS-a. |
| Abstract (english) | BACKGROUND: The aim of this study was to investigate the potential role of the video head impulse test (vHIT) in the detection of brainstem lesions in patients with multiple sclerosis (MS). ----- METHODS: Sixty-eight participants were enrolled and divided into two groups: 39 healthy subjects (HC) (78 ears, 20 females, mean age 25.3±6.3) and 29 MS patients (58 ears, 14 females, mean age 33.7±7.7). Both groups underwent vHIT, and in the MS group the results of MRI were analyzed for the presence of brainstem lesions. vHIT pathology was defined as presence of overt saccades (< 200 ms) or lateral gain lower than 0.8 for lateral canals, and presence of overt saccades (< 200 ms) or posterior/anterior slope lower than 0.7 for anterior and posterior canals. ----- RESULTS: In HC, decreased gain on horizontal canals was found in 8 out of 78 ears (11%), while 16 out of 58 ears (38%) had pathological results in the MS group. Mean gain of the lateral canals (60 ms) was significantly reduced in the MS group compared to HC (0.874±0.143 vs. 0.954±0.170, p=0.004, respectively). Compared to HC overt saccades < 200 ms in lateral canals (p=0.018) and in posterior canals (p=0.011), overt saccades > 200 ms in lateral (p<0.001), anterior (p=0.019) and posterior canals (p=0.009), and covert saccades in anterior (p=0.042) and posterior canals (p=0.046) were more frequent in the MS group. There was a statistically significant association between the presence of BS MR lesions and bilateral pathology on vHIT for lateral semicircular canals (χ(1)=3.982, p=0.046). ----- CONCLUSION: These results indicate that vHIT can detect brainstem dysfunction in patients with MS. |
