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master's thesis
Epilepsy in children caused by hypoxic-ischemic encephalopathy
Zagreb: University of Zagreb, School of Medicine, 2018. urn:nbn:hr:105:091689
Salman, Rima
University of Zagreb
School of Medicine
Department of Pediatrics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Salman, R. (2018). Epilepsy in children caused by hypoxic-ischemic encephalopathy (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:091689

Salman, Rima. "Epilepsy in children caused by hypoxic-ischemic encephalopathy." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:091689

Salman, Rima. "Epilepsy in children caused by hypoxic-ischemic encephalopathy." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:091689

Salman, R. (2018). 'Epilepsy in children caused by hypoxic-ischemic encephalopathy', Master's thesis, University of Zagreb, School of Medicine, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:091689

Salman R. Epilepsy in children caused by hypoxic-ischemic encephalopathy [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2018 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:105:091689

R. Salman, "Epilepsy in children caused by hypoxic-ischemic encephalopathy", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:105:091689

Metadata
TitleEpilepsy in children caused by hypoxic-ischemic encephalopathy
Title (croatian)Epilepsije u dječjoj dobi uzrokovane hipoksično-ishemičnom encefalopatijom
AuthorRima Salman
MentorNina Barišić (mentor)
Committee memberIrena Senečić-Čala (predsjednik povjerenstva)
Committee memberMarija Jelušić (član povjerenstva)
Committee memberNina Barišić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Zagreb
Defense date and country2018-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Hypoxic-ischemic encephalopathy is a condition associated with low uteroplacental blood flow that results in perinatal asphyxia. As a consequence of neonatal oxygen deprivation, perinatal asphyxia at the time of delivery is more common than in utero. Hypoxic-ischemic encephalopathy leads to several unfavorable neurodevelopmental outcomes. Epilepsy, cerebral palsy, mental retardation, visual and hearing problems are some of them. Epilepsy in children with perinatal asphyxia and hypoxic-ischemic encephalopathy is at the primary focus in this graduate thesis paper. Neonatal seizures are seizures that occur during neonatal period – first 28 days of the life of a full-term infant. Fifty percent of neonatal seizures are subtle and characterized by orolingual movements, automatisms, progression and purposeless movements. Most of the newborn seizures usually last 10 seconds to 1-2 minutes. Seizures are mostly repetitive with a median of a few minutes between each seizure. Many different epilepsy types are seen in children some of which being Ohtahara syndrome, West syndrome, and Lennox-Gastaut syndrome. Electroencephalography is the gold standard for diagnosis of neonatal epileptic seizures. 85% of electrographic seizures are usually silent. First line antiepileptic drugs of choice are phenobarbital and phenytoin.
Abstract (croatian)
Hipoksično-ishemična encefalopatija je stanje koje nastaje kao posljedica slabog uteroplacentalnog krvotoka koji rezultira perinatalnom asfiksijom. Pojavljuje se kao posljedica niske saturacije kisikom u novorođenčeta u vrijeme poroda. Hipoksičnoishemična encefalopatija dovodi do nekoliko nepovoljnih neurorazvojnih ishoda kao što su epilepsija, cerebralna paraliza, mentalna retardacija, problemi s vidom i sluhom. Epilepsija i epileptički napadaji uzrokovani perinatalnom asfiksijom i hipokičnoishemičnom encefalopatijom su glavna tema ovoga diplomskoga rada. Epileptički napadaji koji se javljaju tijekom neonatalnog razdoblja, prvih 28 dana života prematurnog i terminskog djeteta. Pedeset posto neonatalnih napadaja su suptilni napadaji za koje su karakteristični orolingvalni pokreti sisanja, gutanja, slinjenja; pokreti poput veslanja i plivanja, multifokalni klonički grčevi. Većina cerebralnih napadaja obično traje 10 sekundi do 1-2 minute. Različite vrste epilepsija mogu se prezentirati u dječjoj dobi kao na primjer Ohtahara sindrom, Westov sindrom i Lennox-Gastautov sindrom. Elektroencefalografija je zlatni standard za dijagnozu cerebralnih epileptičkih napadaja. 85% elektrografskih napadaja obično je tiho to jest nisu klinički prepoznati. Prva linija antiepileptičkih lijekova po izboru su fenobarbital i fenitoin.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:091689
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-04-17 09:24:20