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master's thesis
Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica
Zagreb: University of Zagreb, School of Medicine, 2018. urn:nbn:hr:105:040665
Omerbašić, Mislav
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Omerbašić, M. (2018). Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:040665

Omerbašić, Mislav. "Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:040665

Omerbašić, Mislav. "Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica." Master's thesis, University of Zagreb, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:105:040665

Omerbašić, M. (2018). 'Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica', Master's thesis, University of Zagreb, School of Medicine, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:040665

Omerbašić M. Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2018 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:105:040665

M. Omerbašić, "Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:105:040665

Metadata
TitleFunkcija štitnjače u bolesnika s kroničnom reakcijom transplantanta protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica
Title (english)Thyroid function in patients with chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation
AuthorMislav Omerbašić
MentorTina Dušek (mentor)
Committee memberNadira Duraković (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberTina Dušek (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Uvod: Bolesti štitnjače smatraju se kasnom komplikacijom alogenične transplantacije krvotvornih matičnih stanica. Abnormalna funkcija štitnjače u navedenoj populaciji bolesnika javlja se s učestalošću od 2-56%, ovisno o primarnoj bolesti, vrsti liječenja uslijed i nakon transplantacije te starosti u vrijeme transplantacije. U ovom radu istražujemo postoji li povezanost između bolesti štitnjače i kronične reakcije transplantanta protiv primatelja. ----- Bolesnici i metode: U periodu od lipnja 2013. do ožujka 2018. u studiju je uključeno 118 bolesnika kod kojih je učinjena transplantacija koštane srži. Ovisno o tome jesu li razvili cGvHD, podijeljeni su u dvije grupe: cGvHDpat (n=71) i non-cGvHDpat (n=47). ----- Rezultati: Do poremećaja funkcije štitnjače došlo je u u 30% bolesnika u grupi s cGvHD, odnosno u 19% bolesnika u grupi kod bez cGvHD-a. Najčešće nađena vrsta poremećaja funkcije štitnjače u obje skupine bila je subklinička hipotireoza (67% i 44%). ----- Zaključak: Bolesti štitnjače kasna su komplikacija post alo-TKMS. Nije pokazana signifikantna značajnost da je cGvHD rizični čimbenik za povećanu incidenciju bolesti štitnjače. Također, nije pokazana signifikantna razlika u kumulativnoj incidenciji bolesti štitnjače u grupi cGvHDpat, odnosno non-cGvHDpat. Kod bolesnika koji su uz cGvHD imali i poremećaj funkcije štitnjače pojavile su se u većoj mjeri i bolesti pluća, gastrointestinalnog trakta, jetre, kože, usta i, u najvećem omjeru, bolesti očiju.
Abstract (english)
Introduction: Thyroid diseases are regarded as long-term complications after allogeneic hematopoietic stem cell transplantation. Abnormal thyroid function in this population occurs in 2-56% of patients, depending on primary disease, type of treatment due to and after transplantation and the age at time of transplantation. The aim of this study was to identify whether there is an association between thyroid dysfunction and cGvHD, and to describe the characteristics of the affected patients. ----- Patients and methods: In period from June 2013 till March 2018 118 patients who survived the transplantation were included in this study. Depending on whether they developed cGvHD or not, they were divided into two groups: cGvHDpat (n=71) and non-cGvHDpat (n=47). ----- Results: Abnormal thyroid function occurred in 30% of patients and 19% of controls. The most frequent noticed thyroidopathy in patients and controls was subclinical hypothyreosis, 67% and 44%, respectively. ----- Conclusion: Thyroid dysfunction is a long-term complication after allogeneic hematopoietic stem cell transplantation. We did not prove that chronic graft versus host disease is a significant risk factor for the increased incidence of thyroid diseases in patients after transplantation. There was no significant difference in cumulative incidence of thyroid disease in groups of cGvHDpat and non-cGvHDpat. Dysfunction of lungs, gastrointestinal tract, liver, skin, mouth, and in the biggest ratio, diseases of eyes were more prevalent in patients who developed cGvHD and had abnormal thyroid function.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:040665
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-17 10:09:13