Ischemic heart disease is the most common reason for referral of patients to invasive cardiac treatment - coronary angiography. Hence the majority of patients is taking antiischemic therapy prior to the specified search. Literature data indicate that there are significant differences between the specific types of the antiischemic therapy received by these patients, considering some of their clinical characteristics. The aim of this study was to investigate these differences among patients referred to coronary angiography, with respect to the presence or absence of the most common risk factors for coronary heart disease. This study included a total of 300 patients of the Department of Cardiology KB Merkur. While processing the collected data, we have noticed that patients older than 65 years often took calcium channel blockers and long-acting nitrates compared to those younger than 65 years. Furthermore, men were significantly less likely to take beta blockers and calcium channel blockers compared to women. Patients with hypertension often took beta blockers and calcium channel blockers compared to those without hypertension. Patients with hyperlipidemia took trimetazidine and long-acting nitrates more frequently compared to those without hyperlipidemia. Patients with diabetes were more likely to use beta blockers and less frequently calcium channel blockers compared to those without diabetes. In the end, we did not observe differences in the intake of the antiischemic therapy due to the presence/absence of elevated BMI or smoking. In conclusion, this study shows that presence of the typical risk factors for coronary heart disease significantly affects the type of the antiischemic therapy received by the patients before undergoing invasive cardiac diagnostics. The reasons for such differences are often possible to be found in risk factors, whereas some of them are difficultly explainable and therefore require additional clinical trials.