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master's thesis
Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:679797
Predavec, Nina
University of Zagreb
School of Medicine
Department of Medical Biology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Predavec, N. (2019). Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:679797

Predavec, Nina. "Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:679797

Predavec, Nina. "Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:679797

Predavec, N. (2019). 'Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora', Master's thesis, University of Zagreb, School of Medicine, accessed 24 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:679797

Predavec N. Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 December 24] Available at: https://urn.nsk.hr/urn:nbn:hr:105:679797

N. Predavec, "Serumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:679797

Metadata
TitleSerumska cirkulirajuća DNA kao biljeg invazivnosti trofoblasta i tumora
Title (english)Circulating serum DNA as a marker of trophoblast and tumor invasiveness
AuthorNina Predavec
MentorLjiljana Šerman (mentor)
Committee memberNives Pećina-Šlaus (predsjednik povjerenstva)
Committee memberTamara Nikuševa Martić (član povjerenstva)
Committee memberLjiljana Šerman (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Pojam serumska cirkulirajuća DNA (cfDNA) odnosi se na cirkulirajuće DNA fragmente prisutne u krvi zdravih i oboljelih osoba. Trofoblast i maligni tumori dijele određene karakteristike, poput invazivnosti, sposobnosti metastaziranja i angiogeneze, zbog čega tkivo trofoblasta nazivamo i pseudomalignim tkivom. Stanice trofoblasta i malignih tumora otpuštaju specifične DNA fragmente u krv nazvane cirkulirajuća fetalna DNA (cffDNA) i cirkulirajuća tumorska DNA (ctDNA). cffDNA se primjenjuje u neinvazivnoj prenatalnoj dijagnostici trisomije 21, a njezine povišene koncentracije uočene su u komplikacijama trudnoće poput preeklampsije (PE), intrauterinog zastoja u rastu (IUGR) i prijevremenog porođaja. ctDNA se analizira tekućom biopsijom iz uzorka krvi, koja je u odnosu na klasičnu biopsiju brža, efikasnija i minimalno invazivna metoda. ctDNA posjeduje mutacije identične onima u tumorskim stanicama i ima kratko poluvrijeme života, zbog čega može pružiti informacije o trenutačnom stanju tumora u organizmu. Cilj ovog preglednog rada je sustavno analizirati i predstaviti dosadašnje spoznaje o cfDNA, cffDNA i ctDNA, budući da njihova primjena može rezultirati boljim dijagnostičkim i terapijskim ishodima.
Abstract (english)
The term cell-free DNA (cfDNA) refers to the circulating DNA fragments present in the blood of healthy and diseased individuals. Trophoblast and malignant tumors share certain characteristics, such as invasiveness, metastasis and angiogenesis, which is why the trophoblast tissue is also called the pseudomalignant tissue. Trophoblast and malignant tumor cells release specific DNA fragments into the blood named the cell-free fetal DNA (cffDNA) and circulating tumor DNA (ctDNA). cffDNA is used in non-invasive prenatal diagnosis for trisomy 21, and its elevated concentrations were observed in pregnancy complications such as preeclampsia (PE), intrauterine growth restriction (IUGR) and premature delivery. ctDNA is analyzed by liquid biopsy from a blood sample, which is faster, more efficient and minimally invasive method, compared to the tissue biopsy. ctDNA displays mutations identical to those in tumor cells and has a short half-life, making it able to provide information about the current state of tumor in the body. The aim of this review is to systematically analyze and present the current cfDNA, cffDNA and ctDNA findings, since their application can result in better diagnostic and therapeutic outcomes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:679797
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-23 12:18:17