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master's thesis
Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:757245
Čupić, Ana
University of Zagreb
School of Medicine
Department of Pediatrics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Čupić, A. (2019). Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:757245

Čupić, Ana. "Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:757245

Čupić, Ana. "Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:757245

Čupić, A. (2019). 'Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka', Master's thesis, University of Zagreb, School of Medicine, accessed 24 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:757245

Čupić A. Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 April 24] Available at: https://urn.nsk.hr/urn:nbn:hr:105:757245

A. Čupić, "Prikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:757245

Metadata
TitlePrikaz djeteta s kompliciranom sekundarnom debljinom i odstupanjem u rastu i psihomotoričkom razvoju nejasna uzorka
Title (english)Case study of a child with complicated secondary obesity and deviation in growth and psychomotor development of unclear etiology
AuthorAna Čupić
MentorMario Ćuk (mentor)
Committee memberDanko Milošević (predsjednik povjerenstva)
Committee memberMarija Jelušić (član povjerenstva)
Committee memberMario Ćuk (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Debljina je stanje prekomjernog nakupljanja masnog tkiva koje se najčešće izražava računanjem indeksa tjelesne mase. U dječjoj dobi, zbog velikih i brzih promjena u rastu i razvoju, indeks tjelesne mase nije dovoljno precizan, stoga se koriste posebne centilne krivulje specifične za dob i spol za određivanje odstupanja u težini. Uzroci debljine mogu biti primarni i sekundarni. Sekundarna debljina može biti uzrokovana endokrinološkim poremećajima, monogenetskim mutacijama i genetskim sindromima. Pacijentica M.B. rođena je 2009. godine te je od rođenja prisutna hiperfagija. Krajem prve godine života vidljiva je ekstremna debljina te zamjedbeni zaostaci u psihomotoričkom razvoju. Djevojčica je u trenutku pisanja ovog rada 9 godina stara, debljine iznad 99. centile prema visina-dob i težina-dob krivuljama, a kao posljedicu debljine razvila je metabolički sindrom. Usprkos inicijalnoj sumnji na Prader-Willi sindrom, analiza kromosoma ga je isključila kao uzrok. Etiologija njene debljine još nije otkrivena. S obzirom na kliničku sliku i prethodno isključene uzroke, postavljena je sumnja na monogenetski oblik debljine, koji je potrebno dokazati. Indicirane su daljnje pretrage čitavog genoma u potrazi za uzrokom.
Abstract (english)
Obesity is a state fat tissue excessive accumulation, most commonly expressed by calculating the body mass index. During the childhood, due to the large and fast changes in growth and development, the body mass index is not sufficient, therefore growth charts specified for age and sex are used to determine the weight and growth deviation. Obesity can be either primary or secondary. Secondary obesity can be caused by endocrine disorders, monogenic mutations, and genetic syndromes. Patient M.B. was born in 2009 and has had hyperphagia since birth. By the time she was one year old, the patient presented with extreme obesity and noticeable backlogs in psychomotor development. At the moment of writing this thesis, the patient is a 9-year-old who crossed over the 99th percentile on the special growth charts, and has developed metabolic syndrome as the result of obesity. Despite the initial suspicion of Prader-Willi syndrome, the chromosome analysis excluded it as a cause. The etiology of obesity has not yet been revealed. Based on the clinical picture, suspicion of the monogenic cause of obesity is established, which still needs to be proven. Further analysis of genome is indicated, in search of the etiology.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:757245
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-15 09:25:14